Figure 3

Hypoplastic SMGs are seen in Fgfr2b and Fgf10 heterozygous mice. A. Newborn WT Fgfr2b^+/+ SMG. B. Newborn Fgfr2b^+/- heterozygous SMG. C. Newborn WT Fgf10^+/+ SMG. D. Newborn Fg10^+/- heterozygous SMG. WT Fgfr2b^+/+ (A) and Fgf10^+/+ (C) mice exhibit Late Terminal Bud Stage SMGs consisting of ducts and terminal buds displaying distinct lumina. In contrast, fewer ducts and terminal buds are seen in Fgfr2b^+/- (B) and Fg10^+/- (D) heterozygous SMGs compared to WT littermates. Bar, 50 μm.