Figure 1

Abnormal SMG phenotypes in E12.5 Fgfr2b and Fgf10 null mutants A. E12.5 WT (+/+) mouse. B. E12.5 Fgfr2b^-/- (R2b^-/-) null mouse. C. E12.5 Fg10^-/- null mouse. In the WT mouse (A), the Initial Bud Stage SMG is seen in the mandible ventrolateral to the tongue. By contrast, the SMG bud (outlined in white) in Fgfr2b^-/- (B) and Fg10^-/- (C) mice is extremely small, resembling the earliest Initial Bud Stage SMG. Bar, 50 μm.