Table 1 Changes in transcript levels of the coregulated genes by both tkv and babo pathways after ectopic expression of tkv and babo. (*FC represents the fold changes in gene expression levels between tkv/babo ectopic expression and control. Positive values indicate that the relative expression level of a gene is increased (upregulation) and negative values indicate a decrease (downregulation)).
From: Genome-wide microarray analysis of TGFβ signaling in the Drosophilabrain
Gene/synonym | Signal | FC* | Molecular function | P | ||
|---|---|---|---|---|---|---|
babo | tkv | babo | tkv | |||
Transcription factors | ||||||
usp | 41 | 137 | 8.1 | 27.3 | transcription factor, DNA binding, ligand-dependent nuclear receptor, ecdysteroid hormone receptor | 0.0001 |
CG7839 | 36 | 34 | 1.7 | 1.6 | transcription factor | 0.0007 |
TfIIFβ | 208 | 249 | 1.2 | 1.5 | RNA polymerase II transcription factor | 0.0000 |
CG14422 | 9 | 12 | -3.8 | -2.9 | RNA binding /nucleic acid binding/transcription regulator | 0.0115 |
Antp | 24 | 25 | -1.5 | -1.4 | specific RNA polymerase II transcription factor | 0.0228 |
Enzymes and enzyme regulators | ||||||
ia2 | 351 | 276 | 7.3 | 5.8 | protein tyrosine phosphatase | 0.0000 |
CG1827 | 32 | 26 | 2.3 | 1.8 | N4-(beta-N-acetylglucosaminyl)-L-asparaginase | 0.0010 |
ninaC | 22 | 22 | 1.8 | 1.9 | myosin ATPase, protein serine /threonine kinase | 0.0127 |
G-iα65A | 322 | 259 | 1.8 | 1.4 | heterotrimeric G-protein GTPase | 0.0028 |
Sucb | 148 | 142 | 1.6 | 1.5 | succinate-CoA ligase | 0.0096 |
CG7288 | 117 | 125 | 1.5 | 1.6 | ubiquitin-specific protease | 0.0040 |
CG8913 | 50 | 69 | 1.1 | 1.5 | peroxidase | 0.0000 |
CG9236 | 7 | 5 | -2.6 | -3.4 | calcium-dependent protein serine/threonine phosphatase | 0.0199 |
Transporters | ||||||
CG8533 | 16 | 12 | -2.6 | -3.5 | glutamate-gated ion channel | 0.0000 |
CG6293 | 28 | 49 | -2.5 | -1.4 | L-ascorbate:sodium symporter | 0.0004 |
Atpa | 105 | 126 | -1.5 | -1.3 | sodium/potassium-exchanging ATPase | 0.0003 |
Fatp | 240 | 219 | -1.4 | -1.5 | long-chain fatty acid transporter | 0.0003 |
Signal transducers | ||||||
usp | 41 | 137 | 8.1 | 27.3 | transcription factor, DNA binding, ligand-dependent nuclear receptor, ecdysteroid hormone receptor | 0.0001 |
ninaC | 22 | 22 | 1.8 | 1.9 | myosin ATPase, serine/threonine kinase, calmodulin binding | 0.0127 |
CG8533 | 16 | 12 | -2.6 | -3.5 | glutamate-gated ion channel | 0.0000 |
Structural protein | ||||||
CG14889 | 50 | 50 | -2.8 | -2.8 | extracellular matrix /structural molecule | 0.0023 |
Miscellaneous proteins | ||||||
CG2807 | 78 | 105 | -2.3 | -1.7 | pre-mRNA splicing factor | 0.0034 |
CG32423 | 431 | 428 | -2.1 | -2.1 | RNA binding | 0.0000 |
XRCC1 | 56 | 20 | -1.4 | -3.8 | DNA repair protein | 0.0000 |
Cyp9f2 | 121 | 104 | -1.5 | -1.8 | cytochrome P450 | 0.0012 |
Cyp9f3 | 77 | 70 | -1.5 | -1.7 | pseudogene | 0.0038 |
Unknown | ||||||
CG3857 | 237 | 186 | -2.4 | -3.0 | NA | 0.0000 |
CG7986 | 130 | 117 | -1.5 | -1.7 | NA | 0.0009 |
CG31150 | 66 | 69 | -1.5 | -1.4 | NA | 0.0160 |
CG33187 | 148 | 125 | -1.3 | -1.6 | NA | 0.0035 |