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Table 4 Regulatory genes regulated by TGFβ signaling.

From: Regulation of signaling genes by TGFβ during entry into dauer diapause in C. elegans

Hedgehog and Patched
Gene Type of gene Fold regulation p value Mountain
grd-2 groundhog -2.4 0.0005 14
grd-7 ground domain only 3.8 0.0003 13
grd-6 ground domain only -3.1 0.0002 16
grd-14 ground domain only -8.9 0.0002 16
wrt-7 warthog 6.7 0.01 17
wrt-1 warthog -6.8 0.0001 14
wrt-4 warthog -2.9 0.0003 14
wrt-6 warthog -2.7 0.0005 14
wrt-8 warthog -3.8 0.0005 14
wrt-2 wart domain only -1.8 0.008 14
C56A3.1 ground-like 4.8 0.0001 17
K03B8.7 ground-like 18.9 0.0003 17
ZC487.4 ground-like 3.4 0.009 17
C24G6.7 ground-like -3.6 0.0006 14
F42C5.7 ground-like -2.4 0.0007 1
T02E9.2 ground-like -7.7 0.0001 14
Y75B8A.20 ground-like -13.3 0.0001 14
ZC168.5 ground-like -4.6 0.0001 16
ptc-3 patched -2.1 0.0001 1
ptr-6 patched related -2.3 0.0008 14
ptr-11 patched related -2.6 0.0002 1
ptr-16 patched related -2.7 0.01 14
ptr-18 patched related -3.3 0.0002 16
ptr-23 patched related -2.5 0.0003 6
npc-2 patched family -2.5 0.0004 16
Dauer growth arrest
Gene Type of gene Fold regulation p value  
dbl-1 TGFβ ligand, regulates growth and body size -2.4 0.001  
cdk-4 cyclin dependent kinase -1.9 0.006  
nhr-73 member of a family of NHR genes expressed exclusively in lateral hypodermis (seam cells) -4.4 0.00002  
nhr-74 member of a family of NHR genes expressed exclusively in lateral hypodermis (seam cells) -5.5 0.00005  
nhr-25 similar to NHR in Drosophila ecdysone regulatory cascade, required for embryogenesis and molting -2.4 0.001  
G-protein-coupled receptors and olfaction
gene type of gene fold regulation p value  
srh-75 chemoreceptor 2.6 0.007  
srh-195 chemoreceptor 2.6 0.0009  
srj-32 chemoreceptor 5.8 0.002  
sru-21 chemoreceptor 6.3 0.0007  
32 genes chemoreceptor 1.8 to 6.3 0.05 or less  
15 genes GPCR, not chemoreceptor type 1.8 to 3.6 0.05 or less  
C30F12.6 thyrotropin-releasing hormone receptor ortholog 1.8 0.002  
npp-10 GPCR, nucleoporin -1.8 0.001  
6 genes chemoreceptors -1.8 to -3.8 0.05 or less  
gpa-10 G protein alpha subunit 2.0 0.003  
Y71H2B.7 G protein alpha subunit -1.8 0.0001  
F45B8.2 regulator of G-protein signaling domain 2.4 0.03  
gcy-22 receptor guanylate cyclase 2.7 0.03  
gcy-31 soluble guanylate cyclase 1.8 0.01  
gcy-34 soluble guanylate cyclase 1.8 0.03  
tax-2 cyclic nucleotide gated channel beta subunit 3.0 0.02  
lim-6 homeobox protein, functions to allow chemosensory neurons to sense different molecules 2.0 0.003  
Notch pathway
gene type of gene fold regulation p value  
W02C12.1 notch family 3.9 0.0007  
F47C12.1 notch family 7.4 0.0003  
apx-1 ligand for GLP-1, notch receptor 1.8 0.02  
R03D7.5 shaggy/GSK3 kinase 2.2 0.002  
lag-1 ortholog of CBF1 and Suppressor of Hairless 1.6 0.0003  
Transcriptional regulators
gene type of gene fold regulation p value  
lin-28 cold-shock domain 1.8 0.0001  
lin-29 zinc finger transcription factor -1.9 0.0002  
  1. A complete list of significantly regulated regulatory genes can be found in additional file 4: Table S4.