Figure 2
From: Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome
Embryonic size, lung morphology and histology at various stages of development. Panel A shows the size and general morphology of wild-type (+/+) and Dhcr7-/- (-/-) embryos at E10.5, without significant difference. At P0, the knockout pups were significantly smaller and appeared hypoxic (panel B). Panel C shows dorsal views of lungs from knockout and wild-type at E13.5 and panel D those at P0. Cross-sectional examination at the cardiopulmonary level at E 20.5 (prior to birth) showed normal lobar septation, but lungs from knockout animals were smaller in size and had less distal sac space (cf. panels E and F). Original magnification: Panels A and C, 2X; panels B and D, 0.7X; E and F, 2X. Labels: r, right; l, left; b, bronchial; br, bronchiole; e, esophagus; pa, pulmonary artery; ra, right atrium; la, left atrium; rv, right ventricle; lv, left ventricle.