Figure 1

dFOXO encodes a protein that retains importantfunctional domains found in other FOXO homologues. (A) Schematicrepresentation of the dFOXO cDNA clone LD05569 and its locationin the genomic scaffolding, region AE003703, of the BDGP sequence.(B) ClustalW alignment of the proposed dFOXO amino acid sequencewith that of mammalian homologues (FOXO1a, FOXO3a, and FOXO4) andDaf-16a1. Highlighted are: the T1, S1, and S2 Akt target sequences(yellow shading); the potential DYRK1a/mnb phosphorylation site(arrow, and grey shading); and the forkhead box DNA binding domain (blackbox). "*" indicates nucleotides that are identical in all sequencesin the alignment, ":" indicates conserved substitutions, accordingto the chemical nature of the amino acids, and "." indicates semi-conservedsubstitutions. Colors indicate the chemical nature of the aminoacid; Red = small hydrophobic (including aromatic), Blue = Acidic,Magenta = Basic, and Green = basic amino acids with hydroxyl groupsand/or amine groups.