Figure 1
From: NF-κB DNA-binding activity in embryos responding to a teratogen, cyclophosphamide
External structural anomalies in 17-day fetuses treated with CP alone or in combination with NaSAL. Top row: Left – a control fetus. Right – a fetus treated with NaSAL. No external anomalies were observed in these embryos. Bottom row: Left – a fetus treated with 40 mg/kg CP exhibits severe growth retardation, eventration of the abdominal wall, phocomelia and amelia (hindlimbs), absence of tail, agnathia, open eyes, severe microcephaly. Center: a fetus treated with 15 mg/kg CP exhibits light growth retardation, bowed tail, syndactyly and ectrodactyly. Right: a fetus treated with 15 mg/kg CP and NaSAL exhibits more severe growth retardation than the embryo treated with this dose of CP alone and such anomalies as microcephaly, open eyes, micrognathia, adactyly (forelimbs) and meromelia (hindlimbs), short tail, eventration of the abdominal wall.