Table 8 Proteins found in regenerating limbs of A. mexicanum but not X. laevis and proteins shared by the two species

Signaling

+ APC

YWHAE (-/+)

+ ARL1

YWHAZ (-/+)

+ CCDC88C

GDI2 (NC/+)

- CLTCL1

XG28K (+/+)

- DIXDC1

- ECTO

+ EPHA7

+ EZR

+ FHSB

+ GNB2L1

+ GPR109B

+ INV

-IRF6.2

+ IRS4

+ ISYNA1

+ ITSN2

-LTBP4

+ NET1

+ NOS1

+ OR2AT4

- OR4D10

-PPP2CB

-PTK6

+RAB6B

-SYDE2

-TBC1D17

+TBCK

+ TYK-2

+WNT-8A

- DNAH3

PVALB (-/-)

+ DYNC1LI2

DYNLL1 (-/+)

NC ANXA4

ANXA1 (-/+)

- ASPH

ANXA2 (-/+)

+ ATP11A

ATP2A3 (-/-)

Intracellular transport

+ CACN1A

CASQ1 (+/-)

+ CACNA2D3

SLC25A24 (+/-)

- CAMK2D

- HAK

- MYLC2PL

- SRL

Transcription

1. Chromatin associated

+ Histone 2A

H2AFY2 (+/+)

(H2AFX) (+/+)

NC H2A.ZL1

H1H4B (-/+)

+ H1H3A

- H1H3F

+ H2H2AA4

-H2BE

- H2BF

+ HR

-JMJD1B

+ MTA1

+ NAP1L1-A

2. Transcription factors

+AHCTF1

FUBP1 (NC/+)

- ATF1

TRIM 29 (+/+)

+ CBTF122

-E4F1

+ Lin 28

- MNT

NEUROD2

+ NFATC4

+ NR2C2

+SND1

+ SOX6

- TAF4

+ ZNF259

+ ZNF326

- ZNF559

+ ZNF592

+ ZNF644

- ZNF777

+ Kruppel-like factor

3. RNA processing

- CWC15

SFRS1 (-/-)

+ DDX10

- DDX46

- FBL

- HNRNPF

- HNRNPH2

- HNRNPH3

+ HNRNPL

+ HNRNPU

+ HNRNPAB

+ KHSRP

- LSM4

+ MATR3

- NHP2L1

+ RBM

- SART1

- SFRS12

+ SFRS3

- SNRPD3

SNRPE (-/+)

-SRRM1

TARDBP (+/-)

Translation

Ribosomal proteins:

+ RPL31

RPL12 (+/+)

+ RPS20

RPL15 (+/+)

RPL22 (-/+)

RPL23 (-/+)

RPL30 (+/+)

RPL4 (+/-)

RPL7L1 (+/+)

RPLP0 (+/+)

RPS19 (+/-)

RPS28 (+/+)

RPS6 (+/-)

Translation factors:

+ PABPC1

EEF1A2 (+/+)

- TARSL2

EEF2 (+/+)

+ ETF1

EIF4A1 (+/NC)

EIF4B (+/+)

Cytoskeleton

Muscle proteins:

- MYH3

ACTA1 (-/-)

- MYH4

ACTN3 (-/-)

- MYH7

DES (-/+ & -)

- MYH7B

MYBPC3 (-/+)

- MYL2

MYH13 (-/-)

- MYL3

MYL1 (-/-)

- MYL5

MYLPF (-/-)

- NEB

TNNC2 (-/-)

- OBSCN

TNNT3A (-/-)

- TM7

TPM2 (-/-)

- TPM3

Non-Muscle proteins:

- ACTBL2

ACTG1 (+/+)

- ACTN1

DESPLK (NC/+)

- ACTN4

DESPLK

Isoform II (-/+)

+ ACTR2-A

KRT12 (-/+)

+ EPPK1

KRT19 (+/+)

+ FLNB

KRT5.5 (-/+)

- GOLGA1

PLS3 (-/+)

NC Myo9A

EZR (+/+)

+ NAV1

TUBB2C (+/NC & +)

+ SYNE2

XAKB (-/- & +)

+ TUBA

XAKC (-/+)

+ TUBA4B

CytoKer II (-/+)

+ TUBB4

- DNAH3

MVP (-/+)

- MYH1

DYNLL1 (-/+)

-MYO1C

+ MYO1E

- Myo5A

- PALM2

- PDLIM1

+ CDH5

- CNTNAP4

- FHDC1

+ ST3GAL5

+ SCARF2

- KPNA2

- MYOF

+ PCLO

+ PMFBP1

- SORBS1

ECM

+ Col12A1

FGB (+/+)

+ ColXIII1

FGG (+/+)

+ Col1A1

FN1 (+/+)

+ Col1A1 pre-prot

MAT2 (+/+)

- Col2A1

- Col4A4

+ Col5A2

- DCN

- EHD4

+ FBN1

+ MATN4

- POSTN

- TINAG

+ TNN

Metabolism

- ABCB10

ATP5B (-/NC)

- CS

COX5A (-/+)

- ECHS1

GLUD1 (-/+)

- SLC25A13

- ALDOC

ALDOA (-/-)

- ENO3

ALDOB (-/-)

+ PGAM3

ENO11 (-/-)

PGM1 (-/-)

PGK2 (+/NC)

TPI1 (-/-)

PYGM (-/-)

+ ACACA

AK1B (-/-)

+ ALDH6A1

B3GNT5 (+/-)

- CA3

BHMT (-/-)

-CPNE3

+ DAGLB

+ DHRS4

- DSCR3

- NPC2

+ PAPPA2

- PNPLAS

- SGMS1

+ SULT1A4

Cell protection

Inflammation:

- AOX1

PRDX1 (+/+)

- CYP2F1

+ GSTP1

+ OAS2

+PXDN

+ TLR6

Apoptosis:

+ ABTB1

PDCD6IP (-/+)

- AK2

- AKT1S1

- BIRC6

- FASTKD5

+ IL7R

+ MAST3

+ MICB

+ NEK11

+ PAIRBP1

+ TRAF1

- VDAC1

Chaperones:

- HSP27

CCT2 (+/+)

+ HSP90AB2P

FKBP10 (-/+)

+ HSPB3

HSP90AA1 (-/+)

- PCMT1

HSP90B1 (+/+)

+ SSR1

PDIA3 (-/+)

+ TOR1A

PDIA6 (+/+)

+ HSP90Kda

PPIA (+/+)

isoform1

P4HB (-/+)

Degradation

EXOC7

PSMB1 (+/-)

HACE1

PRSSL1 (-/+)

MME

PSMD2

PSMD7

USP3

Cell cycle

+ CROCC

+ EVI5

- FUS

- LOH11CR2A

- MARK4

-MMCM3

+ NDEL1

+ NMW1

- PPP1CC

- RAN

+ TTN

+ ULA1

- WDR36

- XMAP215