Proteomic analysis of fibroblastema formation in regenerating hind limbs of Xenopus laevis froglets and comparison to axolotl

Table 5 Number of highly regulated Xenopus proteins up regulated and down regulated at each time point after amputation and U/D ratios (bold)

	11 dpa			5dpa			7 dpa			12 dpa
	U	D	U/D	U	D	U/D	U	D	U/D	U	D	U/D
Signaling	39	44	0.9	58	38	1.5	52	34	1.5	60	35	1.7
Transport	30	30	1.0	31	36	0.9	36	32	1.1	35	35	1.0
Transcription	38	47	1.2	52	44	1.2	54	39	1.4	57	43	1.3
CA	9	12	0.8	14	8	1.8	14	8	1.8	15	9	1.7
TFs	18	14	1.3	17	22	0.8	18	18	1.0	20	18	1.1
RP	11	21	0.5	21	14	1.5	22	13	1.7	22	16	1.4
Translation	22	43	0.5	48	22	2.2	57	17	3.4	59	15	3.9
RPs	16	30	0.5	33	16	2.1	40	12	3.3	42	10	4.2
TLFs	6	13	0.5	15	6	2.5	17	5	3.4	17	5	3.4
Cytoskeleton	34	43	0.8	45	50	0.9	48	49	1.0	60	43	1.4
MPs	6	14	0.4	5	23	0.2	4	23	0.2	4	23	0.2
NMPs	28	29	1.0	40	27	1.5	44	26	1.7	56	20	2.8
ECM	24	12	2.0	30	7	4.3	28	8	3.5	28	11	2.5
Metabolism	39	53	1.4	48	76	1.7	45	76	0.6	59	74	0.8
CM	27	37	0.7	18	45	0.4	20	45	0.4	27	43	0.6
NCM	12	16	0.5	30	31	1.0	25	31	0.8	32	31	1.0
Protection	41	29	1.4	41	26	1.6	46	26	1.8	57	24	2.4
INF	23	10	2.3	18	13	1.4	18	14	1.3	25	12	2.1
APO	7	4	1.8	5	5	1.0	5	6	0.8	5	6	0.8
CHA	11	15	0.7	18	8	2.3	23	6	3.8	27	6	4.5
Degradation	28	28	1.0	30	26	1.2	32	25	1.3	39	24	1.6
PRO	11	15	0.7	9	13	0.7	15	13	1.2	17	11	1.5
NPRO	17	13	1.3	21	13	1.6	17	12	1.4	21	13	1.6
Cell cycle	20	25	0.8	21	27	0.8	27	23	1.2	37	17	2.2
G1/S	6	8	0.8	5	8	0.6	7	7	1.0	8	6	1.3
M	4	8	0.5	8	10	0.8	8	9	0.9	13	5	2.6
Other	10	9	1.1	8	9	0.9	12	7	1.7	16	6	2.7

CA = chromatin associated; TFs = transcription factors; RP = RNA processing; RPs = ribosomal proteins; TLFs = translation factors; MPs = muscle proteins; NMPs = non-muscle proteins; CM = carbohydrate metabolism; NCM = non-carbohydrate metabolism; INF = inflammation; APO = apoptosis related; CHA = chaperones; PRO = proteasome associated; NPRO = non-proteasome associated.

ISSN: 1471-213X