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Figure 6 | BMC Developmental Biology

Figure 6

From: Neural crest-specific deletion of Ldb1 leads to cleft secondary palate with impaired palatal shelf elevation

Figure 6

Altered expression of Wnt5a, Osr2 and Pax9 in Wnt1-Cre;Ldb1fl/-mutant palatal shelf. (A-R) Coronal sections of the heads from E13.5 embryos were processed by RNA in situ hybridization. Arrows in E and F, ectopic expression of Wnt5a in the posterior palate. Arrows in G-J, up-regulation of Osr2 in the distal tip of the Ldb1 mutant palatal shelf. Arrows in M-R, down-regulation of Pax9 in the Ldb1 mutant palatal shelf. Abbreviations: na, nasal domain of the palatal shelf; or, oral domain of the palatal shelf. Bar, 0.2 mm.

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