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Figure 4 | BMC Developmental Biology

Figure 4

From: Distinct functions of the laminin β LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila

Figure 4

Joint detachment of alary muscles and Odd-positive pericardial cells in LanB1 and Cg25C mutants. Dorsal views of wild-type and LanB1S0733 and Cg25CS3064 mutant embryos at stage 16/17 stained for Odd (green) and RFP expressed from the reporter genes as in Figure 1 (red) (A-C) or stained for Prc (red) and Tin (green) (D-F). (A) Control embryo with the dorsal ends of all seven pairs of alary muscles terminating near the two rows of Odd-PCs. (B) LanB1S0733 embryo with detached AMs ending near dislocated PCs (arrows). (C) A similar phenotype is detected in Cg25CS3064 embryos. (D) Control embryo showing normal arrangement of Tin+ myocardial and pericardial cells and a contiguous distribution of Prc flanking the outside of the dorsal vessel. (E) LanB1S0733 embryo with irregular Prc distribution often at some distance to the heart (arrows). (F) Cg25CS3064 embryo with contiguous Prc distribution, but some of the pericardial Prc signals are found in laterally located patches (arrows). Tin-positive PCs are associated with the dorsal vessel in both mutants (E, F).

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BMC Developmental Biology

ISSN: 1471-213X

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