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Table 1 CLIC4 expression in adult tissue structures and cell types

From: Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line

CLIC4-GFP-KI mouse tissue Major cell type or structure labeled CLIC4-GFP labeling homozygote CLIC4-GFP labeling heterozygote
Liver Hepatocytes + 0/+
  Sinusoidal lining cells + 0/+
  Bile ductules + 0/+
  Arteriolar smooth muscle* + +
  Venules* + +
Lung Alveolar septae endothelium + +
  Alveolar pneumocytes 0 0
  Venular endothelium + +
  Bronchiolar arteriolar smooth muscle* 0 0
  Pulmonary arteriolar and venular smooth muscle + +
  Bronchiolar epithelium 0 0
  Bronchiolar smooth muscle 0/+ 0/+
Kidney Glomerular tufts- endothelial cells + +
  Glomerular visceral podocytes 0 0
  Proximal convoluted tubules + 0/+
  Distal convoluted tubules 0 0
  Medullary endothelium + 0/+
  Medullary collecting ducts 0 0
Spleen Red pulp tissue - hematopoietic cells + 0
  White pulp -Individual cells, nonlymphoid monocytoid † + 0
Heart Cardiomyocytes Diffuse labeling + 0/+
  Coronary and pulmonary artery and vein smooth muscle + 0/+
Thymus Thymic medullary epithelial cells + +
  Medullary thymocytes 0/+ 0/+
Trachea Tracheal mucosa 0 0
  Perichondrium 0/+ 0
  Chondrocytes + 0/+
Pancreas Islet cells Heterogeneous: + 0
  Exocrine + 0/+
  Ductules + 0/+
Stomach Parietal cells na 0
  Chief cells na 0
  Smooth muscle na 0/+
Esophagus   0 0
Jejunum Villus epithelium na 0
  Lamina proprial endothelium na 0/+
  Smooth muscle na 0/+
Skeletal Muscle Myocytes 0 0
Urinary Bladder Mucosal transitional epithelium 0 0
  Smooth muscle 0 0
Ureter Mucosal transitional epithelium 0 0
  Smooth muscle 0 0
Urethra Mucosal transitional epithelium Variable labeling + 0
Testis Spermatagonia type A Variable labeling + na
  Spermatogonia type B + na
  Sertoli cells 0/+ na
  Interstitial cells of Leydig 0/+ na
  Vas deferens 0 0
Accessory Sex Glands Anterior prostate 0 0
  Dorsal prostate 0 0
  Lateral and ventral prostate + 0/+
  Coagulating gland + 0/+
  Bulbourethral gland + na
Adrenal Gland**   na +
Thyroid Gland Follicular epithelium na Variable labeling 0/+
  1. The table lists major cell types and structures labeled by anti-GFP staining in both homozygous and heterozygous mice. SCORING: 0 = Negative, + = Cell type/tissue positive, 0/+ = Heterogeneous immunolabeling (only some cells label) in homozygous; weak immunolabeling in heterozygous. NOTES: *Vascular smooth muscle myocytes and endothelium were uniformly positive in all tissues unless otherwise noted (homozygous). na = Tissue not available. † Cells morphologically appear to be dendritic cells. **Outer zone of adrenal medullary pheochromocytes subjacent to the corticomedullary junction. Cell types not listed within a given tissue were negative for expression except for vascular endothelium which was labeled throughout all tissues in the homozygous but not universally so in the heterozygous.