Figure 5
From: G1 checkpoint establishment in vivo during embryonic liver development
Low dose IR at E11.5 and E15.5 and its effects on chromosome abnormality in adult liver cells. (A & B) Pregnant mice were exposed to 0.5 Gy IR at embryonic stages 11.5 or 15.5, and the liver cells were then isolated from the mice at adulthood (7 weeks old) and cultured. Chromosome G-banding and spectral karyotyping (SKY) analysis was performed in metaphase cells. Overall aberrant chromosome at metaphase by G-banding (black color) and SKY (RBG color) in the adult liver cells IR at E11.5 (A) and at E15.5 (B). (C) Normal chromosome at metaphase by SKY.