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Figure 7 | BMC Developmental Biology

Figure 7

From: Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. elegans embryo and larva, including the hypodermal fate regulators LIN-26 and ELT-6

Figure 7

Direct transcriptional regulators of lin-39 in the embryo and larva. A) Horizontal lines represent 20 kb of genomic DNA surrounding the lin-39 locus. The lin-39 transcript is shown below the top line, with boxes representing exons. The next horizontal line shows evolutionarily-conserved regions (ECRs; thin vertical lines), the PCR fragments used in the yeast one hybrid assays containing the ECRs (boxes labeled 1–12), and two fragments (pJW3.9 shown, JW5 unlabeled) identified previously using an enhancerless GFP assay [47]. Transcription factors that bind the lin-39 gene are shown above the line (previously reported) or below the line (reported in this work). B) Model for positive feedback loop between egl-18/elt-6 and lin-39. EGL-18 and ELT-6 act via the GATA site in enhancer pJW3.9 to facilitate initiation of lin-39 expression in the embryo, and then LIN-39 acts to positively regulate egl-18/elt-6 expression via the Hox/Pbx binding site in the intron of egl-18[55].

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BMC Developmental Biology

ISSN: 1471-213X

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