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Table 2 Teratomas (7 weeks old and 1 week old) derived from Tenm4 m1 mutant embryos

From: Mouse Tenm4 is required for mesoderm induction

i) 7 weeks old
   +/+ m1/+ m1/m1
  No. of transplantation 9 24 10
  Tumor developed 9 24 4
  Dead or degrading 0 0 6*
  Tumor size    
  large (1.0 - 2.0 cm) 8 24 0
  middle (0.5 - 1.0 cm) 1 0 0
  small (< 0.5 cm) 0 0 4
  Differentiation    
  Ectoderm 9 24 4
  Mesoderm 8 21 0
  Endoderm 4 14 2
ii) 1 week old
   +/+ m1/+ m1/m1
  No. of transplantation 3 8 5
  Tumor developed 3 7 5
  Dead or degrading 0 1 0
  Tumor size    
  large (1.0 - 2.0 cm) 0 0 0
  middle (0.5 - 1.0 cm) 2 5 0
  small (< 0.5 cm) 1 2 5
  Differentiation    
  Ectoderm 3 7 0
  Mesoderm 2 5 0
  Endoderm 2 4 0
  1. Teratomas were assessed by histology after measuring the diameter of the teratoma. The teratoma sizes were categorized as large (1–2 cm), middle (0.5-1 cm) and small (less than 0.5 cm) and the tissue types in teratomas derived from normal and mutant embryos were categorized as ectoderm, endoderm and mesoderm. *Not genotyped due to degrading of teratoma tissue.