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Table 2 Teratomas (7 weeks old and 1 week old) derived from Tenm4 m1 mutant embryos

From: Mouse Tenm4 is required for mesoderm induction

i) 7 weeks old

  

+/+

m1/+

m1/m1

  No. of transplantation

9

24

10

  Tumor developed

9

24

4

  Dead or degrading

0

0

6*

  Tumor size

   

  large (1.0 - 2.0 cm)

8

24

0

  middle (0.5 - 1.0 cm)

1

0

0

  small (< 0.5 cm)

0

0

4

  Differentiation

   

  Ectoderm

9

24

4

  Mesoderm

8

21

0

  Endoderm

4

14

2

ii) 1 week old

  

+/+

m1/+

m1/m1

  No. of transplantation

3

8

5

  Tumor developed

3

7

5

  Dead or degrading

0

1

0

  Tumor size

   

  large (1.0 - 2.0 cm)

0

0

0

  middle (0.5 - 1.0 cm)

2

5

0

  small (< 0.5 cm)

1

2

5

  Differentiation

   

  Ectoderm

3

7

0

  Mesoderm

2

5

0

  Endoderm

2

4

0

  1. Teratomas were assessed by histology after measuring the diameter of the teratoma. The teratoma sizes were categorized as large (1–2 cm), middle (0.5-1 cm) and small (less than 0.5 cm) and the tissue types in teratomas derived from normal and mutant embryos were categorized as ectoderm, endoderm and mesoderm. *Not genotyped due to degrading of teratoma tissue.
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BMC Developmental Biology

ISSN: 1471-213X

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