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Figure 1 | BMC Developmental Biology

Figure 1

From: Thyroid hormone increases fibroblast growth factor receptor expression and disrupts cell mechanics in the developing organ of corti

Figure 1

Thyroid hormone levels regulate Fgf-receptor expression in the cochlea. (A) QPCR results show significantly decreased Fgfr1 (black) and Fgfr3 (white) expression upon treatment with thyroid hormone in vitro (*p-value < 0.05). (B) QPCR expression of Fgfr1 and Fgfr3 is significantly increased when thyroid hormone levels are decreased in vivo (*p-value < 0.05). (C) In situ hybridization for Fgfr1 mRNA at P0 shows increased expression in the greater (asterisk) and lesser (arrowhead) epithelial ridges in hypothyroid cochleae (right) relative to control (left). (D) Fgfr3 mRNA levels at P0 persist in hypothyroid OHCs (right, arrowheads) relative to controls at the base of the cochlea (left, arrowheads). Scale bar, 20 μm, applies to all images. OC, organ of Corti; OHC, outer hair cell.

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BMC Developmental Biology

ISSN: 1471-213X

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