Figure 1From: The Krüppel-like factor 2 and Krüppel-like factor 4 genes interact to maintain endothelial integrity in mouse embryonic vasculogenesisAblation of KLF2 and KLF4 leads to cranial hemorrhaging by E9.5. Light micrographs of E9.5 mouse embryo whole mounts were taken at 16X magnification. A) WT (n = 4); B) KLF2-/- (n = 3); C) KLF4-/- (n = 3); D) KLF2+/-KLF4-/- (n = 3); E) KLF2-/-KLF4+/- (n = 4) embryos are grossly normal. F) KLF2-/-KLF4-/- (n = 3) embryos show hemorrhaging and/or enlarged blood vessels in the head region. Arrowhead indicates hemorrhaging.Back to article page