Figure 1

Patterning cell cycle across the wing imaginal disc. (A) - Schematic of the 3rd instar wing disc. The red and blue region develops to form the notum and hinge while the purple region forms the wing blade. The green line marks the anterior-posterior (A/P) boundary while the red line defines the dorsal-ventral (D/V) boundary. (B) - Across the margin Notch (N) expression triggers the activation of Wingless (Wg). In the margin Wg induces G1 delay via repression of dE2F1 activity in a narrow domain within the anterior compartment and also in a broader region of the posterior compartment. In the anterior compartment, Wg also induces G2 delay in the cells flanking the G1 band by down regulating expression of stg.