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Figure 1 | BMC Developmental Biology

Figure 1

From: Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish

Figure 1

Phylogenetic tree and multiple sequence alignment of PRL protein sequences from human, zebrafish, amphioxus, and Drosophila . (A) Phylogenetic tree of PRL homologue proteins. PRL protein sequences from various species were retrieved from GenBank and corresponding accession numbers are provided in Table 1. The evolutionary history was inferred using the Neighbor-Joining method. The percentage of replicate trees in which the associated taxa clustered together in the bootstrap test (1000 replicates) are shown next to the branches. The tree is drawn to scale, with branch lengths in the same units as those of the evolutionary distances used to infer the phylogenetic tree. The evolutionary distances were computed using the p-distance method and are in the units of the number of amino acid differences per site. Evolutionary analyses were conducted in MEGA5. (B) Multiple sequence alignment of PRL protein sequences from human, zebrafish, amphioxus and Drosophila. Location of conserved catalytic site C(X)5R, WPD loop, polybasic region and prenylation motif CAAX box are indicated. Abbreviations: hPRL: homo sapiens PRL, zfPRL: zebrafish Danio rerio PRL, bfPRL: amphioxus Branchiostoma floridae PRL, dmPRL: Drosophila melanogaster PRL.

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