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Figure 3 | BMC Developmental Biology

Figure 3

From: Heat shock factor-1 intertwines insulin/IGF-1, TGF-β and cGMP signaling to control development and aging

Figure 3

HSF - 1 acts downstream of DAF - 7 to regulate lifespan. HSF-1 is required for the long-lived phenotype of mutant animals defective for TGF-β signaling. HSF-1 deficiency suppresses longevity in daf-7(e1372) mutants. Kaplan-Meyer survival curves were generated by the SPSS software. For comparing daf-7(−) single mutants vs. daf-7(−); hsf-1(−) double mutants or the wild type; p<0.0001 (see the Methods).

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BMC Developmental Biology

ISSN: 1471-213X

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