Protein interactions of the transcription factor Hoxa1

Table 3 Gene Ontology (GO) enrichment analysis

GO term	Obs*	Odds ratio^$	P-value^£	Corr P-value^μ
keratin filament	6	102,352	3,62292E-10	1,19194E-07
pattern specification process	6	12,3435	2,01548E-05	0,00331547
regionalization	5	14,3981	0,000048482	0,00531685
cranial nerve morphogenesis	2	116,248	0,000331888	0,0272978
kidney development	3	21,403	0,000559756	0,0306933
zinc ion binding	16	2,99882	0,000514454	0,0338511
embryonic development	6	5,58735	0,00120012	0,0564059
receptor signaling protein serine/threonine kinase activity	4	8,11769	0,00208634	0,0624006
developmental process	20	2,38882	0,00204634	0,0673246
negative regulation of MAP kinase activity	2	19,4953	0,00596027	0,0676182
regulation of transcription factor import into nucleus	2	31,8952	0,00251195	0,0688694
cation binding	19	2,14904	0,00649842	0,071266
anterior/posterior pattern formation	3	13,3725	0,00198155	0,0724365
cytoskeletal part	8	3,92527	0,00191605	0,0787977
inner ear morphogenesis	2	27,0115	0,00335617	0,0788701

* number of Hoxa1 interactors annotated with the corresponding GO term.
^$ the odds ratio represents the enrichment of the corresponding GO term in the set of Hoxa1 interaction partners, an odds ratio of 10 meaning that the considered GO term is observed 10 times more than expected at random.
^£ probability to see at least the number of proteins corresponding to the GO term at random.
^μP-value including a correction for multiple testing.

ISSN: 1471-213X