Table 2 Interaction partners for Hoxa1 revealed by Y2H screening using AD-Hoxa1
From: Protein interactions of the transcription factor Hoxa1
Protein symbol | Protein name | Gene ID | UniProtKB/Swiss-Prot | Protein function | BiFC signal | Confirmed by co-purification |
|---|---|---|---|---|---|---|
ADCK4 | aarF domain containing kinase 4 | 79934 | Q96D53 | Ser/Thr kinase | / | N |
AGPAT1 | 1-acylglycerol-3-phosphate O-acyltransferase 1 | 10554 | Q99943 | Acetyltransferase | / | N |
BSCL2 (Seipin) | Berardinelli-Seip congenital lipodystrophy 2 | 26580 | Q96G97 | Unknown | / | N |
DKKL1 (Soggy) | dickkopf-like 1 | 27120 | Q9UK85 | Signaling modulator (Wnt pathway) | / | N |
EFEMP2*§ | EGF-containing fibulin-like extracellular matrix protein 2 | 30008 | O95967 | Fibulin-like, unknown | n.d. | Y |
FAM108A1 | family with sequence similarity 108, member A1 | 81926 | Q96GS6 | unknown | Nuclear | Y |
GP9 | glycoprotein IX (platelet) | 2815 | P14770 | Multifunctional receptor, cytoskeleton and signaling regulator (integrins, focal adhesion, PI3K) | / | N |
GRN* | granulin | 2896 | P28799 | Growth factor, transcription factor (in GRN precursor form) | n.d. | Y |
HOXA1§ | homeobox A1 | 3198 | P49639 | Transcription factor (homeodomain) | Nuclear | Y |
HSD3B7 | hydroxy-delta-5-steroid dehydrogenase, 3 β- and steroid delta-isomerase 7 | 80270 | Q9H2F3 | Dehydrogenase | / | N |
IKZF2 (Helios) | IKAROS family zinc finger 2 | 22807 | Q9UKS7 | Transcription fator (zinc finger) | Nuclear | Y |
KRT81 | keratin 81 | 3887 | Q14533 | Intermediate filament | Nuclear and cytoplasmic | Y |
KRTAP26-1§ | keratin associated protein 26-1 | 388818 | Q6PEX3 | Keratin associated | Nuclear | Y |
KRTAP3-2§ | keratin associated protein 3-2 | 83897 | Q9BYR7 | Keratin associated | Nuclear | Y |
KRTAP3-3§ | keratin associated protein 3-3 | 85293 | Q9BYR6 | Keratin associated | / | N |
KRTAP4-12*§ | keratin associated protein 4-12 | 83755 | Q9BQ66 | Keratin associated | Cytoplasmic | Y |
KRTAP5-9 | keratin associated protein 5-9 | 3846 | P26371 | Keratin associated | Vesicular and cytoplasmic | Y |
LIMS1 (PINCH1) | LIM and senescent cell antigen-like domains 1 | 3987 | P48059 | Cytoskeleton and signaling regulator (focal adhesion, integrins, receptor tyrosine kinases) | Nuclear | Y |
MDFI* (I-mfa) | MyoD family inhibitor | 4188 | Q99750 | Signaling regulator (channels, Wnt, JNK pathways) - Transcription factor (I-mfa domain), | Nuclear, vesicular, cytoplasmic | Y |
PCSK5§ | proprotein convertase subtilisin/kexin type 5 | 5125 | Q92824 | Pro-protein convertase | / | N |
PDCD6IP (Alix) | programmed cell death 6 interacting protein | 10015 | Q8WUM4 | Endosome formation and vesicular trafficking, cytoskeleton and signaling regulator (Focal adhesion, TNFR pathway, EGFR, PDGFR) | Vesicular and cytoplasmic | Y |
PFKM | phosphofructokinase, muscle | 5213 | P08237 | Glycolysis | / | N |
PITX2 | paired-like homeodomain 2 | 5308 | Q99697 | Transcription factor (homeodomain) | Nuclear | Y |
PLSCR4§ | phospholipid scramblase 4 | 57088 | Q9NRQ2 | Phospholipid scramblase, transcription factor | Nuclear | Y |
RAB33A | member RAS oncogene family | 9363 | Q14088 | Small GTPase, vesicular trafficking (Ras pathway) | Nuclear | Y |
SMOC1 | SPARC related modular calcium binding 1 | 64093 | Q9H4F8 | Extracellular matrix protein, signaling, migration and differentiation modulator | n.d. | Y |
TRAPPC6A* | trafficking protein particle complex 6A | 79090 | O75865 | Vesicular trafficking | Nuclear | Y |
ZZZ3 | zinc finger, ZZ-type containing 3 | 26009 | Q8IYH5 | Transcription factor (zinc finger) | Nuclear | Y |