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Table 2 Interaction partners for Hoxa1 revealed by Y2H screening using AD-Hoxa1

From: Protein interactions of the transcription factor Hoxa1

Protein symbol Protein name Gene ID UniProtKB/Swiss-Prot Protein function BiFC signal Confirmed by co-purification
ADCK4 aarF domain containing kinase 4 79934 Q96D53 Ser/Thr kinase / N
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 10554 Q99943 Acetyltransferase / N
BSCL2 (Seipin) Berardinelli-Seip congenital lipodystrophy 2 26580 Q96G97 Unknown / N
DKKL1 (Soggy) dickkopf-like 1 27120 Q9UK85 Signaling modulator (Wnt pathway) / N
EFEMP2*§ EGF-containing fibulin-like extracellular matrix protein 2 30008 O95967 Fibulin-like, unknown n.d. Y
FAM108A1 family with sequence similarity 108, member A1 81926 Q96GS6 unknown Nuclear Y
GP9 glycoprotein IX (platelet) 2815 P14770 Multifunctional receptor, cytoskeleton and signaling regulator (integrins, focal adhesion, PI3K) / N
GRN* granulin 2896 P28799 Growth factor, transcription factor (in GRN precursor form) n.d. Y
HOXA1§ homeobox A1 3198 P49639 Transcription factor (homeodomain) Nuclear Y
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 β- and steroid delta-isomerase 7 80270 Q9H2F3 Dehydrogenase / N
IKZF2 (Helios) IKAROS family zinc finger 2 22807 Q9UKS7 Transcription fator (zinc finger) Nuclear Y
KRT81 keratin 81 3887 Q14533 Intermediate filament Nuclear and cytoplasmic Y
KRTAP26-1§ keratin associated protein 26-1 388818 Q6PEX3 Keratin associated Nuclear Y
KRTAP3-2§ keratin associated protein 3-2 83897 Q9BYR7 Keratin associated Nuclear Y
KRTAP3-3§ keratin associated protein 3-3 85293 Q9BYR6 Keratin associated / N
KRTAP4-12*§ keratin associated protein 4-12 83755 Q9BQ66 Keratin associated Cytoplasmic Y
KRTAP5-9 keratin associated protein 5-9 3846 P26371 Keratin associated Vesicular and cytoplasmic Y
LIMS1 (PINCH1) LIM and senescent cell antigen-like domains 1 3987 P48059 Cytoskeleton and signaling regulator (focal adhesion, integrins, receptor tyrosine kinases) Nuclear Y
MDFI* (I-mfa) MyoD family inhibitor 4188 Q99750 Signaling regulator (channels, Wnt, JNK pathways) - Transcription factor (I-mfa domain), Nuclear, vesicular, cytoplasmic Y
PCSK5§ proprotein convertase subtilisin/kexin type 5 5125 Q92824 Pro-protein convertase / N
PDCD6IP (Alix) programmed cell death 6 interacting protein 10015 Q8WUM4 Endosome formation and vesicular trafficking, cytoskeleton and signaling regulator (Focal adhesion, TNFR pathway, EGFR, PDGFR) Vesicular and cytoplasmic Y
PFKM phosphofructokinase, muscle 5213 P08237 Glycolysis / N
PITX2 paired-like homeodomain 2 5308 Q99697 Transcription factor (homeodomain) Nuclear Y
PLSCR4§ phospholipid scramblase 4 57088 Q9NRQ2 Phospholipid scramblase, transcription factor Nuclear Y
RAB33A member RAS oncogene family 9363 Q14088 Small GTPase, vesicular trafficking (Ras pathway) Nuclear Y
SMOC1 SPARC related modular calcium binding 1 64093 Q9H4F8 Extracellular matrix protein, signaling, migration and differentiation modulator n.d. Y
TRAPPC6A* trafficking protein particle complex 6A 79090 O75865 Vesicular trafficking Nuclear Y
ZZZ3 zinc finger, ZZ-type containing 3 26009 Q8IYH5 Transcription factor (zinc finger) Nuclear Y
  1. * Previously reported by Rual et al., 2005.
  2. § Revealed by both AD-ORF and DB-ORF screening.
  3. a Y = yes; N = no.