Table 1 Interaction partners for Hoxa1 revealed by yeast two-hybrid screening using DB-Hoxa1
From: Protein interactions of the transcription factor Hoxa1
Protein symbol | Protein name | Gene ID | UniProtKB/Swiss-Prot | Protein function | BiFC signal | Confirmed by co-purification |
|---|---|---|---|---|---|---|
ADAMTSL4 (TSRC1) | ADAMTS-like 4 | 54507 | Q6UY14 | TNF-induced apopotosis | Nuclear | Y |
BAT2L | HLA-B associated transcript 2-like | 84726 | Q5JSZ5 | Unknown | Nuclear | Y |
C1orf94 | chromosome 1 open reading frame 94 | 84970 | Q6P1W5 | Protein binding | Cytoplasmic | Y |
CCDC33 | coiled-coil domain containing 33 | 80125 | Q8N5R6 | Protein binding | / | N |
EFCAB4B | EF-hand calcium binding domain 4B | 84766 | Q9BSW2 | Calcium binding | Nuclear, and vesicular | Y |
EFEMP2*§ | EGF-containing fibulin-like extracellular matrix protein 2 | 30008 | O95967 | Fibulin-like, unknown | n.d. | Y |
FAM154A | family with sequence similarity 154, member A | 158297 | Q8IYX7 | Unknown | Nuclear, vesicular, cytoplasmic | Y |
FHL5 (ACT) | four and a half LIM domains 5 | 9457 | Q5TD97 | Transcription factor (zinc finger), and kinesin and actin-binding protein | Nuclear | Y |
GPRIN2 | G protein regulated inducer of neurite outgrowth 2 | 9721 | O60269 | G protein interaction | / | N |
HOXA1§ | homeobox A1 | 3198 | P49639 | Transcription factor (homeodomain) | Nuclear | Y |
HOXD3 | homeobox D3 | 3232 | P31249 | Transcription factor (homeodomain) | Nuclear | Y |
HSFY1 | heat shock transcription factor, Y-linked 1 | 86614 | Q96LI6 | Transcription factor (heatshock factor) | / | N |
KRTAP26-1§ | keratin associated protein 26-1 | 388818 | Q6PEX3 | Keratin associated | Nuclear | Y |
KRTAP3-2§ | keratin associated protein 3-2 | 83897 | Q9BYR7 | Keratin associated | Nuclear | Y |
KRTAP3-3§ | keratin associated protein 3-3 | 85293 | Q9BYR6 | Keratin associated | / | N |
KRTAP4-12*§ | keratin associated protein 4-12 | 83755 | Q9BQ66 | Keratin associated | Cytoplasmic | Y |
LGALS13 | lectin, galactoside-binding, soluble, 13 | 29124 | Q9UHV8 | Lipase activity, signaling (regulator of protein kinases) | Nuclear, vesicular, cytoplasmic | Y |
LNX2 | ligand of numb-protein X 2 | 222484 | Q8N448 | Molecular scaffold, E3 ubiquitin ligase, signaling regulator (Notch), associated to cell adhesion molecules | Nuclear and cytoplasmic | Y |
LPXN* | leupaxin | 9404 | O60711 | Signaling (focal adhesion), Transcription factor | Vesicular and cytoplasmic | Y |
MGAT5B (GnT-VB) | mannosyl (α-1,6-)-glycoprotein β-1,6-N-acetyl-glucosaminyltransferase, isozyme B | 146664 | Q3V5L5 | Glycosyltransferase, focal adhesion dynamics | Nuclear | Y |
N4BP2L2 (PFAAP5) | NEDD4 binding protein 2-like 2 | 10443 | Q92802 | Transcription factor or co-regulator | Nuclear | Y |
NR4A1 (Nur77) | nuclear receptor subfamily 4, group A, member 1 | 3164 | P22736 | Transcription factor (nuclear hormone receptor) | / | N |
OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 8473 | O15294 | Glycosyltransferase, transcription co-regulator | Nuclear and cytoplasmic | Y |
PCSK5§ | proprotein convertase subtilisin/kexin type 5 | 5125 | Q92824 | Pro-protein convertase | / | N |
PDLIM7 (LMP-1) | PDZ and LIM domain 7 | 9260 | Q9NR12 | Signaling regulator (BMP, IGFBP pathways) | Cytoplasmic | Y |
PLSCR1* | phospholipid scramblase 1 | 5359 | O15162 | Phospholipid scramblase, signaling regulatior (receptor tyrosine kinases, protein kinases), transcription factor | Nuclear | Y |
PLSCR4§ | phospholipid scramblase 4 | 57088 | Q9NRQ2 | Phospholipid scramblase, transcription factor | Nuclear | Y |
PRDM14 | PR domain containing 14 | 63978 | Q9G2V8 | Histone methyltransferase | Nuclear, vesicular, cytoplasmic | Y |
RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 10616 | Q9BYM8 | Signaling regulator (TNFR, protein kinases), ubiquitin ligase, transcription factor | Nuclear, vesicular, cytoplasmic | Y |
RBPMS (Hermes) | RNA binding protein with multiple splicing | 11030 | Q93062 | Signaling regulator (TGFβ), RNA binding | Nuclear, vesicular, cytoplasmic | Y |
RGS17 | regulator of G-protein signaling 17 | 26575 | Q9UGC6 | Signaling regulator (G proteins) | / | N |
RGS20 | regulator of G-protein signaling 20 | 8601 | O76081 | Signaling regulator (G proteins, protein kinases) | Nuclear and cytoplasmic | Y |
SPRY1 | sprouty homolog 1 | 10252 | O43609 | Signaling regulator (receptor tyrosine kinases) | Nuclear, vesicular, cytoplasmic | Y |
SPRY2 | sprouty homolog 2 | 10253 | O43597 | Signaling regulator (receptor tyrosine kinases, protein kinases) | / | N |
TRAF1 | TNF receptor-associated factor 1 | 7185 | Q13077 | Signaling regulator (TNFR pathway) | Vesicular and cytoplasmic | Y |
TRAF2 | TNF receptor-associated factor 2 | 7186 | Q12933 | Signaling regulator (TNFR pathway) | Vesicular and cytoplasmic | Y |
TRIM23 (ARD1) | tripartite motif-containing 23 | 373 | P36406 | Vesicular trafficking and signaling regulator (TNF pathway), E3 ubiquitin ligase | n.d. | Y |
TRIP6* | thyroid hormone receptor interactor 6 | 7205 | Q15654 | Cytoskeleton and signaling regulator (focal adhesion, TNFR), transcription co-regulator | Nuclear | Y |
ZBTB16 (PLZF) | zinc finger and BTB domain containing 16 | 7704 | Q05516 | Transcription factor (zinc finger), signaling regulator (GPCR, ProRenin Receptor) | Nuclear and vesicular | Y |
ZBTB32 (FAZF) | zinc finger and BTB domain containing 32 | 27033 | Q9Y2Y4 | Transcription factor (zinc finger) | Cytoplasmic | Y |