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Table 1 Interaction partners for Hoxa1 revealed by yeast two-hybrid screening using DB-Hoxa1

From: Protein interactions of the transcription factor Hoxa1

Protein symbol Protein name Gene ID UniProtKB/Swiss-Prot Protein function BiFC signal Confirmed by co-purification
ADAMTSL4 (TSRC1) ADAMTS-like 4 54507 Q6UY14 TNF-induced apopotosis Nuclear Y
BAT2L HLA-B associated transcript 2-like 84726 Q5JSZ5 Unknown Nuclear Y
C1orf94 chromosome 1 open reading frame 94 84970 Q6P1W5 Protein binding Cytoplasmic Y
CCDC33 coiled-coil domain containing 33 80125 Q8N5R6 Protein binding / N
EFCAB4B EF-hand calcium binding domain 4B 84766 Q9BSW2 Calcium binding Nuclear, and vesicular Y
EFEMP2*§ EGF-containing fibulin-like extracellular matrix protein 2 30008 O95967 Fibulin-like, unknown n.d. Y
FAM154A family with sequence similarity 154, member A 158297 Q8IYX7 Unknown Nuclear, vesicular, cytoplasmic Y
FHL5 (ACT) four and a half LIM domains 5 9457 Q5TD97 Transcription factor (zinc finger), and kinesin and actin-binding protein Nuclear Y
GPRIN2 G protein regulated inducer of neurite outgrowth 2 9721 O60269 G protein interaction / N
HOXA1§ homeobox A1 3198 P49639 Transcription factor (homeodomain) Nuclear Y
HOXD3 homeobox D3 3232 P31249 Transcription factor (homeodomain) Nuclear Y
HSFY1 heat shock transcription factor, Y-linked 1 86614 Q96LI6 Transcription factor (heatshock factor) / N
KRTAP26-1§ keratin associated protein 26-1 388818 Q6PEX3 Keratin associated Nuclear Y
KRTAP3-2§ keratin associated protein 3-2 83897 Q9BYR7 Keratin associated Nuclear Y
KRTAP3-3§ keratin associated protein 3-3 85293 Q9BYR6 Keratin associated / N
KRTAP4-12*§ keratin associated protein 4-12 83755 Q9BQ66 Keratin associated Cytoplasmic Y
LGALS13 lectin, galactoside-binding, soluble, 13 29124 Q9UHV8 Lipase activity, signaling (regulator of protein kinases) Nuclear, vesicular, cytoplasmic Y
LNX2 ligand of numb-protein X 2 222484 Q8N448 Molecular scaffold, E3 ubiquitin ligase, signaling regulator (Notch), associated to cell adhesion molecules Nuclear and cytoplasmic Y
LPXN* leupaxin 9404 O60711 Signaling (focal adhesion), Transcription factor Vesicular and cytoplasmic Y
MGAT5B (GnT-VB) mannosyl (α-1,6-)-glycoprotein β-1,6-N-acetyl-glucosaminyltransferase, isozyme B 146664 Q3V5L5 Glycosyltransferase, focal adhesion dynamics Nuclear Y
N4BP2L2 (PFAAP5) NEDD4 binding protein 2-like 2 10443 Q92802 Transcription factor or co-regulator Nuclear Y
NR4A1 (Nur77) nuclear receptor subfamily 4, group A, member 1 3164 P22736 Transcription factor (nuclear hormone receptor) / N
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 8473 O15294 Glycosyltransferase, transcription co-regulator Nuclear and cytoplasmic Y
PCSK5§ proprotein convertase subtilisin/kexin type 5 5125 Q92824 Pro-protein convertase / N
PDLIM7 (LMP-1) PDZ and LIM domain 7 9260 Q9NR12 Signaling regulator (BMP, IGFBP pathways) Cytoplasmic Y
PLSCR1* phospholipid scramblase 1 5359 O15162 Phospholipid scramblase, signaling regulatior (receptor tyrosine kinases, protein kinases), transcription factor Nuclear Y
PLSCR4§ phospholipid scramblase 4 57088 Q9NRQ2 Phospholipid scramblase, transcription factor Nuclear Y
PRDM14 PR domain containing 14 63978 Q9G2V8 Histone methyltransferase Nuclear, vesicular, cytoplasmic Y
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 10616 Q9BYM8 Signaling regulator (TNFR, protein kinases), ubiquitin ligase, transcription factor Nuclear, vesicular, cytoplasmic Y
RBPMS (Hermes) RNA binding protein with multiple splicing 11030 Q93062 Signaling regulator (TGFβ), RNA binding Nuclear, vesicular, cytoplasmic Y
RGS17 regulator of G-protein signaling 17 26575 Q9UGC6 Signaling regulator (G proteins) / N
RGS20 regulator of G-protein signaling 20 8601 O76081 Signaling regulator (G proteins, protein kinases) Nuclear and cytoplasmic Y
SPRY1 sprouty homolog 1 10252 O43609 Signaling regulator (receptor tyrosine kinases) Nuclear, vesicular, cytoplasmic Y
SPRY2 sprouty homolog 2 10253 O43597 Signaling regulator (receptor tyrosine kinases, protein kinases) / N
TRAF1 TNF receptor-associated factor 1 7185 Q13077 Signaling regulator (TNFR pathway) Vesicular and cytoplasmic Y
TRAF2 TNF receptor-associated factor 2 7186 Q12933 Signaling regulator (TNFR pathway) Vesicular and cytoplasmic Y
TRIM23 (ARD1) tripartite motif-containing 23 373 P36406 Vesicular trafficking and signaling regulator (TNF pathway), E3 ubiquitin ligase n.d. Y
TRIP6* thyroid hormone receptor interactor 6 7205 Q15654 Cytoskeleton and signaling regulator (focal adhesion, TNFR), transcription co-regulator Nuclear Y
ZBTB16 (PLZF) zinc finger and BTB domain containing 16 7704 Q05516 Transcription factor (zinc finger), signaling regulator (GPCR, ProRenin Receptor) Nuclear and vesicular Y
ZBTB32 (FAZF) zinc finger and BTB domain containing 32 27033 Q9Y2Y4 Transcription factor (zinc finger) Cytoplasmic Y
  1. * Previously reported by Rual et al., 2005.
  2. § Revealed by both AD-ORF and DB-ORF screening.
  3. a Y = yes; N = no.