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Figure 3 | BMC Developmental Biology

Figure 3

From: Loss of sfrp1 promotes ductal branching in the murine mammary gland

Figure 3

Protein expression analysis of the Axin2 ex vivo . Mouse mammary gland sections were subjected to immunohistochemistry and stained for the Wnt target gene, Axin2 (brown chromogen). Representative ducts are shown from explant mammary gland tissues derived from SFRP1+/+ and SFRP1−/− mice cultured in control media or media containing an exogenous Wnt ligand (Wnt3a) to induce Wnt signaling: (A) SFRP1+/+ in control media, (B) SFRP1−/− in control media, (C) SFRP1+/+ in Wnt3a media, (D) SFRP1−/− in Wnt3a media. Tissue was harvested from and assessed in 6 animals/genotype.

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