TY - JOUR AU - Gordon, C. T. AU - Tan, T. Y. AU - Benko, S. AU - Fitzpatrick, D. AU - Lyonnet, S. PY - 2009 DA - 2009// TI - Long-range regulation at the SOX9 locus in development and disease JO - Journal of medical genetics VL - 46 UR - https://doi.org/10.1136/jmg.2009.068361 DO - 10.1136/jmg.2009.068361 ID - Gordon2009 ER - TY - JOUR AU - Vandermeer, J. E. AU - Ahituv, N. PY - 2011 DA - 2011// TI - cis-regulatory mutations are a genetic cause of human limb malformations JO - Dev Dyn VL - 240 UR - https://doi.org/10.1002/dvdy.22535 DO - 10.1002/dvdy.22535 ID - Vandermeer2011 ER - TY - BOOK AU - Zuniga, A. AU - Probst, S. AU - Zeller, R. PY - 2012 DA - 2012// TI - The molecular basis of human congenital limb malformations PB - Developmental Biology CY - Wiley Interdisciplinary Reviews ID - Zuniga2012 ER - TY - JOUR AU - Ruf, S. AU - Symmons, O. AU - Uslu, V. V. AU - Dolle, D. AU - Hot, C. PY - 2011 DA - 2011// TI - Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor JO - Nat Genet VL - 43 UR - https://doi.org/10.1038/ng.790 DO - 10.1038/ng.790 ID - Ruf2011 ER - TY - JOUR AU - Lettice, L. A. AU - Horikoshi, T. AU - Heaney, S. J. AU - Van Baren, M. J. AU - Van Der Linde, H. C. PY - 2002 DA - 2002// TI - Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly JO - Proc Natl Acad Sci U S A VL - 99 UR - https://doi.org/10.1073/pnas.112212199 DO - 10.1073/pnas.112212199 ID - Lettice2002 ER - TY - JOUR AU - Spitz, F. AU - Gonzalez, F. AU - Duboule, D. PY - 2003 DA - 2003// TI - A global control region defines a chromosomal regulatory landscape containing the HoxD cluster JO - Cell VL - 113 UR - https://doi.org/10.1016/S0092-8674(03)00310-6 DO - 10.1016/S0092-8674(03)00310-6 ID - Spitz2003 ER - TY - JOUR AU - Zuniga, A. AU - Michos, O. AU - Spitz, F. AU - Haramis, A. P. AU - Panman, L. PY - 2004 DA - 2004// TI - Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression JO - Genes Dev VL - 18 UR - https://doi.org/10.1101/gad.299904 DO - 10.1101/gad.299904 ID - Zuniga2004 ER - TY - JOUR AU - Montavon, T. AU - Soshnikova, N. AU - Mascrez, B. AU - Joye, E. AU - Thevenet, L. PY - 2011 DA - 2011// TI - A regulatory archipelago controls Hox genes transcription in digits JO - Cell VL - 147 UR - https://doi.org/10.1016/j.cell.2011.10.023 DO - 10.1016/j.cell.2011.10.023 ID - Montavon2011 ER - TY - JOUR AU - Spitz, F. PY - 2010 DA - 2010// TI - Control of vertebrate Hox clusters by remote and global cis-acting regulatory sequences JO - Adv Exp Med Biol VL - 689 UR - https://doi.org/10.1007/978-1-4419-6673-5_4 DO - 10.1007/978-1-4419-6673-5_4 ID - Spitz2010 ER - TY - JOUR AU - Zeller, R. AU - Zuniga, A. PY - 2007 DA - 2007// TI - Shh and Gremlin1 chromosomal landscapes in development and disease JO - Curr Opin Genet Dev VL - 17 UR - https://doi.org/10.1016/j.gde.2007.07.006 DO - 10.1016/j.gde.2007.07.006 ID - Zeller2007 ER - TY - JOUR AU - Benazet, J. D. AU - Bischofberger, M. AU - Tiecke, E. AU - Goncalves, A. AU - Martin, J. F. PY - 2009 DA - 2009// TI - A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning JO - Science VL - 323 UR - https://doi.org/10.1126/science.1168755 DO - 10.1126/science.1168755 ID - Benazet2009 ER - TY - JOUR AU - Capdevila, J. AU - Tsukui, T. AU - Rodriquez Esteban, C. AU - Zappavigna, V. AU - Izpisua Belmonte, J. C. PY - 1999 DA - 1999// TI - Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin JO - Mol Cell VL - 4 UR - https://doi.org/10.1016/S1097-2765(00)80393-7 DO - 10.1016/S1097-2765(00)80393-7 ID - Capdevila1999 ER - TY - JOUR AU - Michos, O. AU - Panman, L. AU - Vintersten, K. AU - Beier, K. AU - Zeller, R. PY - 2004 DA - 2004// TI - Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis JO - Development VL - 131 UR - https://doi.org/10.1242/dev.01251 DO - 10.1242/dev.01251 ID - Michos2004 ER - TY - JOUR AU - Zuniga, A. AU - Haramis, A. P. AU - McMahon, A. P. AU - Zeller, R. PY - 1999 DA - 1999// TI - Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds JO - Nature VL - 401 UR - https://doi.org/10.1038/44157 DO - 10.1038/44157 ID - Zuniga1999 ER - TY - JOUR AU - Zeller, R. AU - Lopez-Rios, J. AU - Zuniga, A. PY - 2009 DA - 2009// TI - Vertebrate limb bud development: moving towards integrative analysis of organogenesis JO - Nat Rev Genet VL - 10 UR - https://doi.org/10.1038/nrg2681 DO - 10.1038/nrg2681 ID - Zeller2009 ER - TY - JOUR AU - Sagai, T. AU - Hosoya, M. AU - Mizushina, Y. AU - Tamura, M. AU - Shiroishi, T. PY - 2005 DA - 2005// TI - Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb JO - Development VL - 132 UR - https://doi.org/10.1242/dev.01613 DO - 10.1242/dev.01613 ID - Sagai2005 ER - TY - JOUR AU - Lettice, L. A. AU - Hill, A. E. AU - Devenney, P. S. AU - Hill, R. E. PY - 2008 DA - 2008// TI - Point mutations in a distant sonic hedgehog cis-regulator generate a variable regulatory output responsible for preaxial polydactyly JO - Hum Mol Genet VL - 17 UR - https://doi.org/10.1093/hmg/ddm370 DO - 10.1093/hmg/ddm370 ID - Lettice2008 ER - TY - JOUR AU - Maas, S. A. AU - Suzuki, T. AU - Fallon, J. F. PY - 2011 DA - 2011// TI - Identification of spontaneous mutations within the long-range limb-specific Sonic hedgehog enhancer (ZRS) that alter Sonic hedgehog expression in the chicken limb mutants oligozeugodactyly and silkie breed JO - Dev Dyn VL - 240 UR - https://doi.org/10.1002/dvdy.22634 DO - 10.1002/dvdy.22634 ID - Maas2011 ER - TY - JOUR AU - Amano, T. AU - Sagai, T. AU - Tanabe, H. AU - Mizushina, Y. AU - Nakazawa, H. PY - 2009 DA - 2009// TI - Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription JO - Dev Cell VL - 16 UR - https://doi.org/10.1016/j.devcel.2008.11.011 DO - 10.1016/j.devcel.2008.11.011 ID - Amano2009 ER - TY - JOUR AU - Capellini, T. D. AU - Di Giacomo, G. AU - Salsi, V. AU - Brendolan, A. AU - Ferretti, E. PY - 2006 DA - 2006// TI - Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression JO - Development VL - 133 UR - https://doi.org/10.1242/dev.02395 DO - 10.1242/dev.02395 ID - Capellini2006 ER - TY - JOUR AU - Galli, A. AU - Robay, D. AU - Osterwalder, M. AU - Bao, X. AU - Benazet, J. D. PY - 2010 DA - 2010// TI - Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development JO - PLoS Genet VL - 6 UR - https://doi.org/10.1371/journal.pgen.1000901 DO - 10.1371/journal.pgen.1000901 ID - Galli2010 ER - TY - JOUR AU - Lettice, L. A. AU - Williamson, I. AU - Wiltshire, J. H. AU - Peluso, S. AU - Devenney, P. S. PY - 2012 DA - 2012// TI - Opposing Functions of the ETS Factor Family Define Shh Spatial Expression in Limb Buds and Underlie Polydactyly JO - Dev Cell VL - 22 UR - https://doi.org/10.1016/j.devcel.2011.12.010 DO - 10.1016/j.devcel.2011.12.010 ID - Lettice2012 ER - TY - JOUR AU - Wang, B. AU - Fallon, J. F. AU - Beachy, P. A. PY - 2000 DA - 2000// TI - Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor gradient in the Developing Vertebrate Limb JO - Cell VL - 100 UR - https://doi.org/10.1016/S0092-8674(00)80678-9 DO - 10.1016/S0092-8674(00)80678-9 ID - Wang2000 ER - TY - JOUR AU - Mo, R. AU - Freer, A. M. AU - Zinyk, D. L. AU - Crackower, M. A. AU - Michaud, J. PY - 1997 DA - 1997// TI - Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development JO - Development VL - 124 ID - Mo1997 ER - TY - JOUR AU - Litingtung, Y. AU - Dahn, R. D. AU - Li, Y. AU - Fallon, J. F. AU - Chiang, C. PY - 2002 DA - 2002// TI - Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity JO - Nature VL - 418 UR - https://doi.org/10.1038/nature01033 DO - 10.1038/nature01033 ID - Litingtung2002 ER - TY - JOUR AU - Lopez-Rios, J. AU - Speziale, D. AU - Robay, D. AU - Scotti, M. AU - Osterwalder, M. PY - 2012 DA - 2012// TI - GLI3 Constrains Digit Number by Controlling Both Progenitor Proliferation and BMP-Dependent Exit to Chondrogenesis JO - Developmental Cell VL - 22 UR - https://doi.org/10.1016/j.devcel.2012.01.006 DO - 10.1016/j.devcel.2012.01.006 ID - Lopez-Rios2012 ER - TY - JOUR AU - te Welscher, P. AU - Zuniga, A. AU - Kuijper, S. AU - Drenth, T. AU - Goedemans, H. J. PY - 2002 DA - 2002// TI - Progression of Vertebrate Limb Development through SHH-Mediated Counteraction of GLI3 JO - Science VL - 298 UR - https://doi.org/10.1126/science.1075620 DO - 10.1126/science.1075620 ID - te Welscher2002 ER - TY - JOUR AU - Khokha, M. K. AU - Hsu, D. AU - Brunet, L. J. AU - Dionne, M. S. AU - Harland, R. M. PY - 2003 DA - 2003// TI - Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning JO - Nat Genet VL - 34 UR - https://doi.org/10.1038/ng1178 DO - 10.1038/ng1178 ID - Khokha2003 ER - TY - JOUR AU - Zhou, F. AU - Leder, P. AU - Zuniga, A. AU - Dettenhofer, M. PY - 2009 DA - 2009// TI - Formin1 disruption confers oligodactylism and alters Bmp signaling JO - Hum Mol Genet VL - 18 UR - https://doi.org/10.1093/hmg/ddp185 DO - 10.1093/hmg/ddp185 ID - Zhou2009 ER - TY - JOUR AU - Panman, L. AU - Galli, A. AU - Lagarde, N. AU - Michos, O. AU - Soete, G. PY - 2006 DA - 2006// TI - Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling JO - Development VL - 133 UR - https://doi.org/10.1242/dev.02529 DO - 10.1242/dev.02529 ID - Panman2006 ER - TY - JOUR AU - Soshnikova, N. AU - Montavon, T. AU - Leleu, M. AU - Galjart, N. AU - Duboule, D. PY - 2010 DA - 2010// TI - Functional analysis of CTCF during mammalian limb development JO - Dev Cell VL - 19 UR - https://doi.org/10.1016/j.devcel.2010.11.009 DO - 10.1016/j.devcel.2010.11.009 ID - Soshnikova2010 ER - TY - JOUR AU - Vokes, S. A. AU - Ji, H. AU - Wong, W. H. AU - McMahon, A. P. PY - 2008 DA - 2008// TI - A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb JO - Genes Dev VL - 22 UR - https://doi.org/10.1101/gad.1693008 DO - 10.1101/gad.1693008 ID - Vokes2008 ER - TY - JOUR AU - Birney, E. AU - Stamatoyannopoulos, J. A. AU - Dutta, A. AU - Guigo, R. AU - Gingeras, T. R. PY - 2007 DA - 2007// TI - Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project JO - Nature VL - 447 UR - https://doi.org/10.1038/nature05874 DO - 10.1038/nature05874 ID - Birney2007 ER - TY - JOUR AU - Myers, R. M. AU - Stamatoyannopoulos, J. AU - Snyder, M. AU - Dunham, I. AU - Hardison, R. C. PY - 2011 DA - 2011// TI - A user's guide to the encyclopedia of DNA elements (ENCODE) JO - PLoS biology VL - 9 UR - https://doi.org/10.1371/journal.pbio.1001046 DO - 10.1371/journal.pbio.1001046 ID - Myers2011 ER - TY - JOUR AU - Pearl, E. J. AU - Barker, D. AU - Day, R. C. AU - Beck, C. W. PY - 2008 DA - 2008// TI - Identification of genes associated with regenerative success of Xenopus laevis hindlimbs JO - BMC Dev Biol VL - 8 UR - https://doi.org/10.1186/1471-213X-8-66 DO - 10.1186/1471-213X-8-66 ID - Pearl2008 ER - TY - JOUR AU - Nicoli, S. AU - Gilardelli, C. N. AU - Pozzoli, O. AU - Presta, M. AU - Cotelli, F. PY - 2005 DA - 2005// TI - Regulated expression pattern of gremlin during zebrafish development JO - Gene expression patterns : GEP VL - 5 UR - https://doi.org/10.1016/j.modgep.2004.11.001 DO - 10.1016/j.modgep.2004.11.001 ID - Nicoli2005 ER - TY - JOUR AU - Boisvert, C. A. AU - Mark-Kurik, E. AU - Ahlberg, P. E. PY - 2008 DA - 2008// TI - The pectoral fin of Panderichthys and the origin of digits JO - Nature VL - 456 UR - https://doi.org/10.1038/nature07339 DO - 10.1038/nature07339 ID - Boisvert2008 ER - TY - JOUR AU - Lettice, L. A. AU - Heaney, S. J. AU - Purdie, L. A. AU - Li, L. AU - de Beer, P. PY - 2003 DA - 2003// TI - A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly JO - Hum Mol Genet VL - 12 UR - https://doi.org/10.1093/hmg/ddg180 DO - 10.1093/hmg/ddg180 ID - Lettice2003 ER - TY - JOUR AU - Scherz, P. J. AU - Harfe, B. D. AU - McMahon, A. P. AU - Tabin, C. J. PY - 2004 DA - 2004// TI - The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells JO - Science VL - 305 UR - https://doi.org/10.1126/science.1096966 DO - 10.1126/science.1096966 ID - Scherz2004 ER - TY - JOUR AU - Verheyden, J. M. AU - Sun, X. PY - 2008 DA - 2008// TI - An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth JO - Nature VL - 454 UR - https://doi.org/10.1038/nature07085 DO - 10.1038/nature07085 ID - Verheyden2008 ER - TY - JOUR AU - Bandyopadhyay, A. AU - Tsuji, K. AU - Cox, K. AU - Harfe, B. D. AU - Rosen, V. PY - 2006 DA - 2006// TI - Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis JO - PLoS Genet VL - 2 UR - https://doi.org/10.1371/journal.pgen.0020216 DO - 10.1371/journal.pgen.0020216 ID - Bandyopadhyay2006 ER - TY - JOUR AU - Tzchori, I. AU - Day, T. F. AU - Carolan, P. J. AU - Zhao, Y. AU - Wassif, C. A. PY - 2009 DA - 2009// TI - LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth JO - Development VL - 136 UR - https://doi.org/10.1242/dev.026476 DO - 10.1242/dev.026476 ID - Tzchori2009 ER - TY - JOUR AU - Nissim, S. AU - Hasso, S. M. AU - Fallon, J. F. AU - Tabin, C. J. PY - 2006 DA - 2006// TI - Regulation of Gremlin expression in the posterior limb bud JO - Dev Biol VL - 299 UR - https://doi.org/10.1016/j.ydbio.2006.05.026 DO - 10.1016/j.ydbio.2006.05.026 ID - Nissim2006 ER - TY - JOUR AU - te Welscher, P. AU - Fernandez-Teran, M. AU - Ros, M. A. AU - Zeller, R. PY - 2002 DA - 2002// TI - Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling JO - Genes Dev VL - 16 UR - https://doi.org/10.1101/gad.219202 DO - 10.1101/gad.219202 ID - te Welscher2002 ER - TY - JOUR AU - Yang, X. AU - Li, C. AU - Herrera, P. L. AU - Deng, C. X. PY - 2002 DA - 2002// TI - Generation of Smad4/Dpc4 conditional knockout mice JO - Genesis VL - 32 UR - https://doi.org/10.1002/gene.10029 DO - 10.1002/gene.10029 ID - Yang2002 ER - TY - JOUR AU - Logan, M. AU - Martin, J. F. AU - Nagy, A. AU - Lobe, C. AU - Olson, E. N. PY - 2002 DA - 2002// TI - Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer JO - Genesis VL - 33 UR - https://doi.org/10.1002/gene.10092 DO - 10.1002/gene.10092 ID - Logan2002 ER - TY - JOUR AU - Wen, X. AU - Lai, C. K. AU - Evangelista, M. AU - Hongo, J. A. AU - de Sauvage, F. J. PY - 2010 DA - 2010// TI - Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation JO - Molecular and cellular biology VL - 30 UR - https://doi.org/10.1128/MCB.01089-09 DO - 10.1128/MCB.01089-09 ID - Wen2010 ER - TY - JOUR AU - Ong, C. T. AU - Corces, V. G. PY - 2011 DA - 2011// TI - Enhancer function: new insights into the regulation of tissue-specific gene expression JO - Nature reviews Genetics VL - 12 UR - https://doi.org/10.1038/nrg2957 DO - 10.1038/nrg2957 ID - Ong2011 ER - TY - JOUR AU - Zeller, R. PY - 2010 DA - 2010// TI - The temporal dynamics of vertebrate limb development, teratogenesis and evolution JO - Curr Opin Genet Dev VL - 20 UR - https://doi.org/10.1016/j.gde.2010.04.014 DO - 10.1016/j.gde.2010.04.014 ID - Zeller2010 ER - TY - JOUR AU - St-Jacques, B. AU - Dassule, H. R. AU - Karavanova, I. AU - Botchkarev, V. A. AU - Li, J. PY - 1998 DA - 1998// TI - Sonic hedgehog signaling is essential for hair development JO - Curr Biol VL - 8 UR - https://doi.org/10.1016/S0960-9822(98)70443-9 DO - 10.1016/S0960-9822(98)70443-9 ID - St-Jacques1998 ER - TY - JOUR AU - Maynard, T. M. AU - Jain, M. D. AU - Balmer, C. W. AU - LaMantia, A. S. PY - 2002 DA - 2002// TI - High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletion JO - Mamm Genome VL - 13 UR - https://doi.org/10.1007/s00335-001-2115-X DO - 10.1007/s00335-001-2115-X ID - Maynard2002 ER - TY - JOUR AU - Morgan, B. A. AU - Conlon, F. L. AU - Manzanares, M. AU - Millar, J. B. AU - Kanuga, N. PY - 1996 DA - 1996// TI - Transposon tools for recombinant DNA manipulation: characterization of transcriptional regulators from yeast, Xenopus, and mouse JO - Proc Natl Acad Sci U S A VL - 93 UR - https://doi.org/10.1073/pnas.93.7.2801 DO - 10.1073/pnas.93.7.2801 ID - Morgan1996 ER - TY - JOUR AU - Tesson, L. AU - Heslan, J. M. AU - Menoret, S. AU - Anegon, I. PY - 2002 DA - 2002// TI - Rapid and accurate determination of zygosity in transgenic animals by real-time quantitative PCR JO - Transgenic research VL - 11 UR - https://doi.org/10.1023/A:1013928600442 DO - 10.1023/A:1013928600442 ID - Tesson2002 ER - TY - JOUR AU - Ovcharenko, I. AU - Nobrega, M. A. AU - Loots, G. G. AU - Stubbs, L. PY - 2004 DA - 2004// TI - ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes JO - Nucleic acids research VL - 32 UR - https://doi.org/10.1093/nar/gkh355 DO - 10.1093/nar/gkh355 ID - Ovcharenko2004 ER - TY - JOUR AU - Larkin, M. A. AU - Blackshields, G. AU - Brown, N. P. AU - Chenna, R. AU - McGettigan, P. A. AU - McWilliam, H. AU - Valentin, F. AU - Wallace, I. M. AU - Wilm, A. AU - Lopez, R. AU - Thompson, J. D. AU - Gibson, T. J. AU - Higgins, D. G. PY - 2007 DA - 2007// TI - ClustalW and ClustalX version 2 JO - Bioinformatics VL - 23 UR - https://doi.org/10.1093/bioinformatics/btm404 DO - 10.1093/bioinformatics/btm404 ID - Larkin2007 ER -