Figure 1
From: Expression of canonical WNT/β-CATENIN signaling components in the developing human lung
Real-time qRT-PCR was performed to examine the mRNA expression levels (mean ± sem) of canonical WNT/β-CATENIN signaling components, including WNT ligands ( WNT2 , WNT7B ), WNT receptors ( FZD4 , FZD7 , LRP5 , LRP6 ), WNT transducers ( DVL2 , DVL3 , GSK-3β , β-CATENIN , APC , AXIN2 ), WNT transcription factors ( TCF4 , LEF1 ) and WNT inhibitors or antagonists ( SOSTDC1 ) in the developing human lung at 7 W, 12 W, 17 W and 21 W (W: Weeks of gestation) (A-D). Data were normalized to the average mRNA level of β-actin at 7 W. Statistical difference is indicated by asterisks (* P < 0.05, ** P < 0.01).