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Figure 9 | BMC Developmental Biology

Figure 9

From: β-catenin/Tcf-signaling appears to establish the murine ovarian surface epithelium (OSE) and remains active in selected postnatal OSE cells

Figure 9

Decrease in ß-catenin/Tcf-signaling OSE cells  in vitro.  OSE cells isolated from P5-P9 mice were cultured in alpha MEM supplemented with 4% FBS. The number of lacZ+ cells was estimated after incubation with the fluorescent substrate CMFDG. LacZ+ cell numbers doubled within first four days of culture and decreased subsequently with prolong culture. In contrast, lacZ-negative cells increased steadily. These results suggest that lacZ+ cells lose their ability to signal through the ß-catenin/Tcf-signaling pathway and become non-signaling.

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