Figure 6

Knockdown of desmosomal cadherins affects convergent-extension movements. Representative DIC images of wild type and morphant embryos at 9-11 somites to illustrate convergent-extension defects produced by knocking down zfDsc1 and zfDsg2. A-C Dorsal views showing abnormal somite structure. D-F Lateral views showing shortening of embryonic axis (head and tail indicated by upper and lower arrowhweads, respectively). G-L Higher magnification pictures showing medio-lateral widening of somites (double headed arrows in G-I), kinking of notochord (arrows in H, K) and loss of chevron structure of somites (J-L). Scale bars = 100 μm (A-F) and 50 μm (G-L).