Figure 3
From: In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1
Thyroid development in Nkx2-1 mutant embryos. Hematoxylin and eosin staining of sagittal sections from wild type and mutant mouse embryos at E11.5 (panels A to E) and E16.5 (panels F to J). At E11.5 PM/PM mutant embryos show a thyroid bud (E, arrow) whose morphology cannot be distinguished from that of the wild type embryos (A, arrow) while in the other mutant embryos the thyroid bud is not visible (panels B-D, asterisks). At E16.5, PM/PM thyroid is present but appears hypoplastic (compare J versus F, arrows). In Nkx2-1 null, ΔNH 2 and ΔCOOH mutants the thyroid is absent(panels G-I, asterisks). Original magnification ×200 for all panels.