Figure 2
From: In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1
Pituitary development in Nkx2-1 mutant embryos. Hematoxylin and eosin staining of sagittal sections from wild type and mutant mouse embryos at E11.5 (panels A to E) and E16.5 (panels F to J). ΔCOOH and PM mutants at E11.5 (panels D and E,) show a Ratke's pouch not different to that of wild type (A); on the contrary Nkx2-1 null and Δ NH 2 embryos show only a rudimentary Ratke's pouch (panels B and C, arrows). At E16,5, the size of the developing pituitary is comparable in wild type(F), ΔCOOH (I) and PM mutants (J) while Nkx2-1 null and ΔNH 2 mutant embryos have no pituitary (panels G and H, asterisks). Original magnification ×200 for all panels.