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Table 3 Common cofactors implicated in ecdysone signalling in multiple cell types.

From: Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogastercell lines

Cell Lines

Common Cofactors

Full Name

Imaginal Specific Cofactors

(D20 and L1)

alien

kis

Mys

Pc

alien

kismet

myospheroid

Polycomb

Embryonic Specific Cofactors

(Kc and S2)

boss

MED23

mor

Orc5

Rfx

sas

Taf2

bride of sevenless

Mediator complex subunit 23

moira

Origin recognition complex subunit 5

Rfx

stranded at second

TBP-associated factor 2

D20 and Kc

Jhl-1

mus304

Tbp-1

Juvenile hormone-inducible protein 1

mutagen-sensitive 304

Tat-binding protein-1

D20 and S2

CG11970

Chd1

Elf3-S10

hb

Mia

Myb

Neb

Tai

zfh2

CG11970

Chromodomain-helicase-DNA-binding protein

eIF3-S10

hunchback

meiosis I arrest

Myb oncogene-like

nebbish

taiman

Zn finger homeodomain 2

Kc and L1

Babo

brm

E2f2

EcR

baboon

brahma

E2F transcription factor 2

Ecdysone receptor

L1 and S2

CG1582

hyd

MED16

CG1582

hyperplastic discs

Mediator complex subunit 16

D20, Kc, and L1

Elf5

eIF5

D20, L1, and S2

RfC3

RfC3

D20, Kc, L1, and S2

Tst

twister

  1. Seven of the cofactors tested appear to be embryonic specific while four appear to be imaginal cell specific.