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Figure 4 | BMC Developmental Biology

Figure 4

From: Conserved and non-conserved enhancers direct tissue specific transcription in ancient germ layer specific developmental control genes

Figure 4

otx1b CNES and modified BAC. (A) UCSC browser snapshot showing synteny around otx1b and the functional CNEs Ox2, Ox3 and Ox4. (B) Whole mount RNA in situ hybridization showing expression of otx1b in the neural plate at 6 hpf. (C) Whole mount RNA in situ hybridization showing expression of otx1b in the forebrain and otic vesicle at 24 hpf. (D) Modified BAC showing expression in forebrain and otic vesicle at 24 hpf. (E) CNE Ox4 drives expression in the neural plate at 6 hpf. CNE Ox2 (F) and Ox3 (G) drives expression in the forebrain at 36 hpf and 48 hpf respectively. Both fail to drive expression in the otic vesicle. FB-forebrain. OV-otic vesicle

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BMC Developmental Biology

ISSN: 1471-213X

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