Figure 1

A schematic of retinal vascular development. The key stages in vascular development of the normal mouse retina (top) and the Lama1^nmf223 mutant retina (bottom) are represented in this diagram. Solid red lines depict blood vessels while blue lines indicate vessels which originate in the Lama1 mutant retinas but traverse the ILM into the vitreous beyond the peripapillary region. Broken red lines depict the regressing hyaloid vasculature. At P1, vessels have begun forming in both the control and Lama1 mutant retinas. The fetal vessels of vitreous (FVV), which includes the tunica TVL and the VHP, are regressing in the control by P7 and the primary retinal plexus is complete, while in the Lama1 mutants, the FVV have undergone some regression but those closest to the retina have proliferated. Retinal vessels (blue) have traversed the ILM to anastomose with the VHP vessels in P7 Lama1 mutants. The retinal vasculature is complete at P21 in the control retina and no hyaloid vessels remain in the vitreous. The FVV in the Lama1 retina at P21 persist and have proliferated and formed a retinal vasculature. (TVL-Tunica vasculosa lentis; VHP-vasa hyaloidea propria).