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Table 2 Fold change in mRNA levels in the Sox6 KO skeletal muscles compared to control

From: Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6

  TA EDL Gas Sol
Mouse ID# 1 2 3 1 2 3 1 2 3 1 2 3
Sox6 0.75 0.42 0.09 0.43 0.38 0.07 0.38 0.53 0.10 0.20 0.31 0.12
Myh1 (IIx/d) 2.08 1.68 0.20 1.31 5.77 5.49 6.79 14.80 2.11 0.01 0.03 1 × 10-3
Myh2 (IIa) 5.00 1.96 0.80 3.08 2.11 4.72 6.63 5.77 1.85 0.02 0.02 u.d.
Myh4 (IIb) 0.17 0.01 0.01 0.11 0.04 0.02 0.25 1 × 10-3 0.02 0.16 0.16 0.01
Myh6 (α) 78.79 252.99 1.03 24.19 25.37 6.65 3.54 4.13 2.42 4.03 1.61 0.65
Myh7 (β) 9042.52 2177.81 94.12 1318.30 728.63 1611.29 21.86 3.59 9.68 3.60 1.00 1.20
Myh7b 31.37 n.d. 0.49 3.98 n.d. 1.39 14.30 n.d. 3.06 1.51 n.d. 0.34
Myl2 1496.57 n.d. 7.07 57.22 n.d. 55.59 7.37 n.d. 2.70 1.91 n.d. 1.31
Tnnc1 6830.19 4622.47 474.50 665.43 687.83 128.70 91.24 167.58 14.52 0.81 2.98 1.53
Tnni1 2619.20 1867.14 610.53 433.38 552.33 861.06 116.58 69.76 24.71 2.64 2.58 2.59
Tnni2 0.34 0.50 0.20 0.36 0.89 0.15 0.46 0.76 0.35 0.01 0.14 2 × 10-3
Tnnt1 4348.43 1594.44 157.77 1011.39 510.51 153.18 131.98 59.18 5.07 2.93 1.76 1.56
Tnnt2 2.45 1.88 2.08 2.31 0.59 1.55 1.23 2.65 1.37 2.59 1.12 1.85
Tnnt3 0.45 0.40 0.43 0.28 0.89 0.58 0.34 0.38 0.19 4 × 10-3 0.06 2 × 10-4
Chrng (fetal) 0.89 4.63 4.94 0.73 1.80 1.82 1.23 1.80 3.29 2.78 1.17 8.26
Chrne (adult) 0.44 0.30 0.28 0.14 0.18 0.76 0.16 0.15 0.14 0.24 0.34 1.44
Prox1 29.26 10.30 9.66 22.84 6.68 17.04 16.21 8.41 3.34 3.79 2.26 1.27
Tead1 1.83 n.d. 0.99 0.63 n.d. 0.98 1.25 n.d. 0.78 1.02 n.d. 0.94
Tead4 3.03 n.d. 1.26 1.34 n.d. 1.08 1.23 n.d. 1.08 0.96 n.d. 1.11
Tcf4 1.94 n.d. 1.70 0.88 n.d. 1.54 1.68 n.d. 1.15 0.88 n.d. 1.43
Hdac9 4.44 n.d. 2.68 1.51 n.d. 1.79 7.56 n.d. 1.42 1.34 n.d. 0.75
Myod1 0.73 1.01 0.70 0.73 1.02 2.11 1.47 1.44 1.17 1.51 1.77 0.72
Myog 3.64 1.52 2.24 1.98 1.84 3.00 2.61 1.12 0.95 4.48 1.89 1.35
Mb 1.84 1.47 1.48 0.66 2.30 1.75 1.88 3.50 1.54 0.77 1.62 1.09
Sdha 1.18 0.74 0.39 0.70 0.74 0.50 0.79 0.60 0.32 0.68 0.59 0.55
Ppargc1a 1.28 1.39 0.53 0.82 0.78 0.35 0.63 1.46 0.42 0.53 0.71 0.19
  1. Sox6 was inactivated using MCK-Cre mice. Mouse 1 and mouse 2 are two month-old, and mouse 3 is three month-old. Gene names in bold: associated with Sox6 binding. Gene names in italics: slow fiber specific sarcomere proteins, or transcription factors reported that are preferentially expressed in slow fibers. n.d.: not determined. u.d.: undetected in Sox6 KO mouse. Control expression level = 1.00.