Figure 5From: Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6Differences of expression levels of Sox6 target genes between control and Sox6 KO perinatal mice. RT-qPCR was performed using total RNA from skeletal muscle of control (Sox6f/f) and Sox6 KO (Sox6f/f; MCK-Cre) newborn (postnatal day 1) mice. Expression levels in Sox6 KO mice were divided by those in control mice, and represented as mean ± SD (n = 3). The broken line corresponds to the expression ratio of 1, indicating equal expression level between the KO and control mice. (*) P < 0.05; (**) P < 0.005. Fiber type specific genes: Myh1, Myh2, Myh7, My7b, Myl2 (also expressed in the heart), Tnnc1 (also expressed in the heart), Tnni1, Tnnt1; cardiac isoforms: Myh6, Tnnt2; developmental isoform: Myl4; transcription factors: Prox1, Tcf4, Tead1, Tead4, Nfatc3; histone modification enzymes: Hdac9, Hdac11.Back to article page