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Figure 2 | BMC Developmental Biology

Figure 2

From: Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling

Figure 2

Sd and Yki are required for the ectopic cell proliferation in scrib mutant eye disc clones. Mutant eye/antennal disc clones were generated with ey-FLP and are positively marked by GFP expression (green, or magenta in the merges). Grayscale is BrdU. A white bar indicates the location of the MF. (A-D) RNAi-mediated knockdown of sd in clones does not alter the normal pattern of BrdU incorporation in the eye/antennal disc (A), whilst scrib1 clones expressing bskDN are large and ectopically proliferate posterior to the MF (B). Knockdown of sd in scrib1 clones expressing bskDN reduces the ectopic cell proliferation in the mutant clones posterior to the MF (C), and a similar rescue is shown by knockdown of yki (D).

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