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Figure 6 | BMC Developmental Biology

Figure 6

From: Transdifferentiation from cornea to lens in Xenopus laevis depends on BMP signalling and involves upregulation of Wnt signalling

Figure 6

Expression of selected transdifferentiation genes during development. In situ hybridisation of five regeneration associated genes (RAG). Dark blue staining marks expression, and a white arrow indicates the position of the lens. A) Nipsnap1 expression appears in lens cells at stage 30 (A) and is also found in the pronephros (pn) and branchial arches (ba) from stage 32 (B). At stage 36, Nipsnap1 expression is seen in the pronephros and pronephritic duct (pnd) and otic vesicle (ov) as well as in the periphery of the lens (C). D) Tbp1b is expressed predominantly in lens, otic vesicle and branchial arches at stage 32. E) Tcf7 is expressed in lens and choroid fissure of the retina (cf), the midbrain-hindbrain junction (m/h), cement gland (cg), otic vesicle and pronephritic duct at at stage 32. F) Pdik1l is expressed in the developing lens and retina (re) and branchial arches at stage 32. G) Dvl2 is expressed in eye tissues but is not specific, with expression extending throughout the embryo including the somites (s), otic vesicle and branchial arches. Embryos are oriented with anterior to the left and dorsal uppermost.

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