Figure 2

Histology of WT and BMP inhibited (N1) tadpole eyes following lentectomy. (A-D) Representative histological sections through the eyes of transgenic N1 tadpoles 1, 3, 5 and 7 days after lentectomy. Inset in A shows arrows pointing to columnar corneal cells (E-H) Representative sections of wild type eyes at 1, 3, 5 and 7 days after lentectomy. Inset in E indicates columnar corneal cells (arrows). Arrowheads in F indicate the forming lentoid moving into the vitreous. Both transgenic and wild type eyes were subjected to heat shock at -3, 24 and 48 hours relative to lentectomy. Abbreviations: c, cornea; h, hypertrophic cells; i, iris (pigmented epithelium); l, lens; r, retina; v, vitreous. Scale bars in D and H corresponds to 50 μm and applies to all panels. Inset scale bar in A and E corresponds to 10 μm.