Figure 1
From: Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling
etv5b and pea3 expression is reduced in ext2 mutants. Lateral view (left panels) and dorsal view (right panels) of etv5b (A-D, M-P) and pea3 (E-L) expression in 38 hpf ext2 mutants (C, D, G, H, K, L, O, P) and WT embryos (A, B, E, F, I, J, M, N). (I-P) Embryos treated with 8 μM SU5402 3 h prior to fixation. Note that pea3 expression in WT embryos is only marginally affected by the inhibitor (compare E-F with I-J) while pea3 expression is almost completely inhibited by the same treatment in ext2 mutants (compare G-H with K-L). The arrows label the MHB.