Figure 2

Altered positioning of rods in relation to red cones in response to retinoic acid treatment. Embryos treated with DMSO (A) or 0.3 μM RA (B) at 36 hpf and fixed at 60 hpf were doubly hybridized as whole mounts with probes corresponding to rod opsin (red color) and red cone opsin (green color). Following RA treatment, rods are more abundant, cones are more sparsely distributed, and rods display spacing characteristics more typical of cones. Bar = 50 μm.