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Figure 2 | BMC Developmental Biology

Figure 2

From: The Drosophila Netrin receptor frazzled/DCC functions as an invasive tumor suppressor

Figure 2

Tumor-like phenotypes are observed in adult flies when fra loss of function clones survive during development. fra3mutant tumor-like growths (arrow in A) are detected in a small percentage of animals in which clones are generated during development. A high magnification view of the growth present on an adult leg (arrow in A) is provided in B; lack of GFP expression in this growth marks fra mutant cells in the panel at right). Although most animals in which P35-rescued fra4mutant clones are generated do not survive to adulthood, interesting phenotypes are observed in escaper flies (C). P35-rescued fra4mutant cells generated in the eye (marked by expression of GFP, red in color due to presence of w+ transgenes) are detected in the wing (C, region marked by arrow is magnified at right). Clones were generated with a hsFLP driver in A and B and with eyFLP in C.

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