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Figure 4 | BMC Developmental Biology

Figure 4

From: ATRX has a critical and conserved role in mammalian sexual differentiation

Figure 4

Whole mount in situ hybridization of ATRX in the developing mouse and marsupial embryo. mRNA distribution is shown by dark blue/purple staining, while tissues are bleached white. In the E11.5 mouse, mRNA was concentrated in the developing limbs, tail and craniofacial regions of the fetus. Staining was also evident in the brain, neural tube and dorsal root ganglia (A, B). mRNA persisted in each of these domains throughout mouse development and was distinct in the forming hand and foot plate, developing phallus, fore and hind brain, dorsal root ganglia, neural tube and craniofacial regions (C-F). Identical zones of mRNA expression were detected in the near-term tammar wallaby fetus (G,H). HL - hind limb, FL - fore limb, P- phallus, FB - fore brain, HB - hind brain, NT - neural tube, CF - craniofacial regions, T - tail. Scale bar = 2 mm.

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