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Figure 6 | BMC Developmental Biology

Figure 6

From: The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development

Figure 6

Loss of S1P 1 R inhibits cardiac growth at E12.5. (A) The average myocardial area at the level of cardiac cushions and the cardiac cushions were measured. S1P1R-/- hearts had less ventricular tissue but were normal for cardiac cushion size, both AV canal and outflow tract. S1P1R+/+, N = 5; S1P1R+/-, N = 3; S1P1R-/-, N = 4. *P ≤ 0.02. (B) The length of the heart was measured from the AV canal cushion to the apex of the heart. S1P1R-/- hearts were shorter than S1P1R+/+ and S1P1R+/- littermates. S1P1R+/+, N = 3; S1P1R+/-, N = 3; S1P1R-/-, N = 3. *P ≤ 0.0006.

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