Figure 1
From: PAPC and the Wnt5a/Ror2 pathway control the invagination of the otic placode in Xenopus
Expression of xPAPC, Ror2, xFz7 and Wnt5a in the otic vesicle. (A, A') ISH for xPAPC expression at tailbud stage (stage 28). (A) Enlarged head shows a strong signal in the otic region. (A') Additional expression domain at the tail organizer. (B, C, D) xPAPC expression in the otic vesicle at stages 24, 26 and 28. Vertical line indicates level of section. The corresponding transversal sections (B', C', D') reveal a strong restriction to the lateral epithelium. The scheme shows axis orientation in the otic vesicle in regard to the axial organs neural tube and notochord. (E, F, G) Otic expression of Ror2 (E), xFz7 (F) and Wnt5a (G) in a stage 28 embryo. A, anterior; D, dorsal; L, lateral; M, medial; N, notochord; OV, otic vesicle; P, posterior; T, neural tube; V, ventral; Scale bar (A, C, F) 500 μm, (A') 600 μm, (C') 100 μm.