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Figure 6 | BMC Developmental Biology

Figure 6

From: The Enhancer of split transcription factor Her8a is a novel dimerisation partner for Her3 that controls anterior hindbrain neurogenesis in zebrafish

Figure 6

her8a expression is independent of endogenous Notch signaling in the early neural plate. Dorsal views of flat-mounted embryos analyzed at the 3-somite stage for the expression of the genes indicated. A-F. Ectopic Notch activation (injection of capped NICD mRNA) abolished neurog1 expression (B) and activates her8a (D) and her4.1 (F) compared to non-injected embryos (ctrl). G-J'. Notch blockade (incubation in the gamma-secretase inhibitor DAPT) increases neurog1 expression within proneural clusters (H) but leaves her8a expression intact (J) at early neural plate stages compared to embryos treated with a vehicle only (ctrl). G'-J' are high magnification views of the areas boxed in G-J.

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