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Table 1 Summary of Changes in Regulatory Gene Expression

From: FGF signalling through RAS/MAPK and PI3K pathways regulates cell movement and gene expression in the chicken primitive streak without affecting E-cadherin expression

Gene Name

Reference Sequence

Preingression Vs. Lateral Epiblast

Preingression Epiblast + SU5402 (FGFR)

Preingression Epiblast + U0126 (MAPK)

Preingression Epiblast + LY294002 (PI3K)

T T, brachyury homolog

NM_204940

U1,3

D1,2,3

D1,2,3

NC1,2,3

TBX4 T-box 4

NM_001030537

NC1

D1

NC1

D1

TBX6 T-box 6

NM_001030367

U1,2,3

D1, 2,3

NC1,2,3

D1,2,3

EOMES eomesodermin homolog

XM_426003

U1

D1,2

D1

D1

ETV1 ets variant gene 1 (Er81)

NM_204917

U1,2,3

D1,2

D1

NC1

ETV4 ets variant gene 4 (Pea3)

XM_418106

NC1,2,3

D1,2,3

D1,3

NC1,3

ELK3 ETS-domain protein (SRF accessory protein 2)

NM_001030749

U1,3

D1,2

D1

NC1

EVX1 even-skipped homeobox 1

XM_425994.2

NC1

D1,2

D1

D1

DLX1 distal-less homeobox 1

NM_001045842.2

NC1

D1

NC1

D1

TLX3 T-cell leukemia homeobox 3

XM_001233188.1

U1

D1

ND

ND

CDX4 caudal type homeobox 4

NM_204614.1

U3

D3

D3

ND

SNAI2 snail homolog 2

XM_419196.2

U2,3

D2,3

D3

D3

ZIC3 Zic family member 3

AF188736

NC1

D1

D1

NC1

JAZF1 JAZF zinc finger 1

XM_418732.2

NC1

D1

NC1

D1

XBP1 X-box binding protein 1

NM_001006192.1

U1

D1

D1

D1

ATF3 activating transcription factor 3

XM_419429.2

U1

D1

D1

NC1

ATF4 activating transcription factor 4

NM_204880.1

U1

D1

D1

D1

POU3F1 POU domain, class 3, transcription factor 1 (Oct 6)

XM_427826.1

NC1,3

D1

D1

D1

HDAC7A histone deacetylase 7A

NM_001031402.1

NC1

D1

NC1

D1

HDAC8 histone deacetylase 8

XM_420178.2

NC1

D1

D1

D1

FGF3 fibroblast growth factor 3

NM_205327.1

U1,

D1

D1

NC1

FGF4 fibroblast growth factor 4

NM_001031546.1

U1,2,3

D1,2,3

NC1,3

D3

FGF8 fibroblast growth factor 8

NM_001012767.1

U1,3

NC1,2,3

NC/U1,3

NC1,3

FGF18 fibroblast growth factor 18

NM_204714.1

U1

D1

D1

NC1

SPRY1 sprouty homolog 1, antagonist of FGF signalling

NM_001097524

U1,2,3

D1,2,3

D1,3

NC1,3

SPRY2 sprouty homolog 2

NM_204800.1

U1,3

D1,3

D1

D1

SPRY3 sprouty homolog 3

 

U1

ND

D1

NC1

SPRED2 sprouty-related, EVH1 domain containing 2

XM_419341.2

U1

D1

D1

NC1

DUSP6 dual specificity phosphatase 6

NM_204354

U1,3

D1

D1

NC1

IL17RD interleukin 17 receptor D (SEF)

NM_204515.1

NC1

D1

D1

NC1

WNT3 wingless-type MMTV integration site family, member 3

NM_204675

U1,3

NC1

NC1

NC1

WNT8A wingless-type MMTV integration site family, member 8A

NM_205531.1

U1,2,3

D1,2,3

D1,2,3

D1,2,3

WNT5B wingless-type MMTV integration site family, member 5B

NM_001037269.1

U1,2,3

D1,2,3

D1,3

NC1,3

FZD7 frizzled homolog 7

NM_204221.1

U1,3

D1

NC1

NC1

LOC417741 similar to secreted Xwnt8 inhibitor sizzled

NM_204675

NC1

D1

D1

D1

NOTCH1 Notch homolog 1, translocation-associated

XM_415420

U1,2,3

D1,2,3

D1,2,3

NC1,2,3

DLL1 delta-like 1

NM_204973.1

U1,2,3

D1,2,,3

D1,3

NC1,3

SNW1 SNW domain containing 1

BX931222

U1

D1

NC1

D1

NET1 neuroepithelial cell transforming gene 1

NM_001030648.1

NC1

D1

D1

D1

CER1 cerberus 1, cysteine knot superfamily, homolog

NM_204823.1

U1,3

D1

U1

D1

CFC1 cripto, FRL-1, cryptic family 1

NM_204700.1

U1

D1

D1

NC1

EPHA1 EPH receptor A1

NM_204360.1

U1,2,3

D1,2,3

D1,3

D1,3

EDNRB endothelin receptor type B

XM_417001.2

U1

D1,2

D1

D1

EDNRB2 endothelin receptor B subtype 2

NM_204120.1

U1,3

D1,3

D1

NC1

PDGFRA platelet-derived growth factor receptor, alpha polypeptide

NM_204749.1

U1,3

D1,3

D3

NC3

ROR1 receptor tyrosine kinase-like orphan receptor 1

NM_204509.1

U1

D1

D1

D1

  1. U: Gene Expression Increased. D: Gene Expressed Reduced. NC: No Change. ND: Not determined
  2. Superscripts: Result Confirmed by: 1. Microarray; 2. PCR; 3. In Situ Hybridization