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Table 1 Summary of Changes in Regulatory Gene Expression

From: FGF signalling through RAS/MAPK and PI3K pathways regulates cell movement and gene expression in the chicken primitive streak without affecting E-cadherin expression

Gene Name Reference Sequence Preingression Vs. Lateral Epiblast Preingression Epiblast + SU5402 (FGFR) Preingression Epiblast + U0126 (MAPK) Preingression Epiblast + LY294002 (PI3K)
T T, brachyury homolog NM_204940 U1,3 D1,2,3 D1,2,3 NC1,2,3
TBX4 T-box 4 NM_001030537 NC1 D1 NC1 D1
TBX6 T-box 6 NM_001030367 U1,2,3 D1, 2,3 NC1,2,3 D1,2,3
EOMES eomesodermin homolog XM_426003 U1 D1,2 D1 D1
ETV1 ets variant gene 1 (Er81) NM_204917 U1,2,3 D1,2 D1 NC1
ETV4 ets variant gene 4 (Pea3) XM_418106 NC1,2,3 D1,2,3 D1,3 NC1,3
ELK3 ETS-domain protein (SRF accessory protein 2) NM_001030749 U1,3 D1,2 D1 NC1
EVX1 even-skipped homeobox 1 XM_425994.2 NC1 D1,2 D1 D1
DLX1 distal-less homeobox 1 NM_001045842.2 NC1 D1 NC1 D1
TLX3 T-cell leukemia homeobox 3 XM_001233188.1 U1 D1 ND ND
CDX4 caudal type homeobox 4 NM_204614.1 U3 D3 D3 ND
SNAI2 snail homolog 2 XM_419196.2 U2,3 D2,3 D3 D3
ZIC3 Zic family member 3 AF188736 NC1 D1 D1 NC1
JAZF1 JAZF zinc finger 1 XM_418732.2 NC1 D1 NC1 D1
XBP1 X-box binding protein 1 NM_001006192.1 U1 D1 D1 D1
ATF3 activating transcription factor 3 XM_419429.2 U1 D1 D1 NC1
ATF4 activating transcription factor 4 NM_204880.1 U1 D1 D1 D1
POU3F1 POU domain, class 3, transcription factor 1 (Oct 6) XM_427826.1 NC1,3 D1 D1 D1
HDAC7A histone deacetylase 7A NM_001031402.1 NC1 D1 NC1 D1
HDAC8 histone deacetylase 8 XM_420178.2 NC1 D1 D1 D1
FGF3 fibroblast growth factor 3 NM_205327.1 U1, D1 D1 NC1
FGF4 fibroblast growth factor 4 NM_001031546.1 U1,2,3 D1,2,3 NC1,3 D3
FGF8 fibroblast growth factor 8 NM_001012767.1 U1,3 NC1,2,3 NC/U1,3 NC1,3
FGF18 fibroblast growth factor 18 NM_204714.1 U1 D1 D1 NC1
SPRY1 sprouty homolog 1, antagonist of FGF signalling NM_001097524 U1,2,3 D1,2,3 D1,3 NC1,3
SPRY2 sprouty homolog 2 NM_204800.1 U1,3 D1,3 D1 D1
SPRY3 sprouty homolog 3   U1 ND D1 NC1
SPRED2 sprouty-related, EVH1 domain containing 2 XM_419341.2 U1 D1 D1 NC1
DUSP6 dual specificity phosphatase 6 NM_204354 U1,3 D1 D1 NC1
IL17RD interleukin 17 receptor D (SEF) NM_204515.1 NC1 D1 D1 NC1
WNT3 wingless-type MMTV integration site family, member 3 NM_204675 U1,3 NC1 NC1 NC1
WNT8A wingless-type MMTV integration site family, member 8A NM_205531.1 U1,2,3 D1,2,3 D1,2,3 D1,2,3
WNT5B wingless-type MMTV integration site family, member 5B NM_001037269.1 U1,2,3 D1,2,3 D1,3 NC1,3
FZD7 frizzled homolog 7 NM_204221.1 U1,3 D1 NC1 NC1
LOC417741 similar to secreted Xwnt8 inhibitor sizzled NM_204675 NC1 D1 D1 D1
NOTCH1 Notch homolog 1, translocation-associated XM_415420 U1,2,3 D1,2,3 D1,2,3 NC1,2,3
DLL1 delta-like 1 NM_204973.1 U1,2,3 D1,2,,3 D1,3 NC1,3
SNW1 SNW domain containing 1 BX931222 U1 D1 NC1 D1
NET1 neuroepithelial cell transforming gene 1 NM_001030648.1 NC1 D1 D1 D1
CER1 cerberus 1, cysteine knot superfamily, homolog NM_204823.1 U1,3 D1 U1 D1
CFC1 cripto, FRL-1, cryptic family 1 NM_204700.1 U1 D1 D1 NC1
EPHA1 EPH receptor A1 NM_204360.1 U1,2,3 D1,2,3 D1,3 D1,3
EDNRB endothelin receptor type B XM_417001.2 U1 D1,2 D1 D1
EDNRB2 endothelin receptor B subtype 2 NM_204120.1 U1,3 D1,3 D1 NC1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide NM_204749.1 U1,3 D1,3 D3 NC3
ROR1 receptor tyrosine kinase-like orphan receptor 1 NM_204509.1 U1 D1 D1 D1
  1. U: Gene Expression Increased. D: Gene Expressed Reduced. NC: No Change. ND: Not determined
  2. Superscripts: Result Confirmed by: 1. Microarray; 2. PCR; 3. In Situ Hybridization
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