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Figure 6 | BMC Developmental Biology

Figure 6

From: Serum response factor is required for cell contact maintenance but dispensable for proliferation in visceral yolk sac endothelium

Figure 6

Adhesion molecule gene expression is disrupted in SRF-null VYS tissues. Quantification of mRNA levels in whole VYS tissues from wild type and Tie2Cre+/0·Srff/f embryos. Fold change was calculated using 2^ΔΔCt, where a value of '1' indicates no change. Bars represented as * indicate no signal was detected in samples from Tie2Cre+/0·Srff/f embryos. Values represent fold change with positive SEM only. Genes listed: serum response factor (Srf), β-actin (Actb), smooth muscle α-actin (Acta2), platelet-endothelial adhesion molecule-1 (Pecam1), vascular endothelial cadherin (Cdh5, a.k.a. VE-Cad), β-catenin (Ctnnb1), claudin 5 (Cldn5), tight junction protein 1 (Tjp1, a.k.a. ZO-1), integrin-α5 (Itga5), integrin-β1 (Itgb1), vinculin (Vcl), fibronectin-1 (Fn1).

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