Table 1 A summary of the genes described in this work.
| Â | Gene | Description | Genbank | expression | expression domain at E14.5 | Publication on gut or pancreas | ||
|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | E8.5, endo | Â | Â | Expression or function | Publication |
d5 DE > 5 and d8 DE > 5, compared with ES, ECT, LPM, PAM, Mesendoderm, d5 DE | AI464131 | expressed sequence AI464131 | BG063189 | whole gut | epithelium | mesenchyme | ― | ― |
|  | Akr1c19 | aldo-keto reductase family 1, member C19 | BG073853 | AIP | epithelium |  | ― | ― |
| Â | DAF1/CD55 | decay accelerating factor 1 | NM_010016 | AIP, lateral gut | Â | Â | endoderm | Cell Struct. Func. 2010 |
| Â | Foxq1 | forkhead box Q1 | NM_008239 | AIP | Â | Â | stomach | Gastroenterogy, 2008 |
| Â | Nptx2 | neuronal pentraxin 2 | NM_016789 | whole gut | Â | Â | pancreatic cancer | Cancer Epidemiol Biomarkers Prev, 2008 |
| Â | Parm1 | Riken cDNA 9130213B05 gene | NM_145562 | anterior endoderm | tip | Â | E10.5 pancreas | BMC Dev. Biol., 2007 |
|  | Pga5 | pepsinogen 5, group I | NM_021453 | lateral gut |  |  | ― | ― |
| Â | Tmem184a | transmembrane protein 184a | BC019731 | AIP, lateral gut | epithelium | Â | E12.5~, pancreas exocrine | Dev Dyn., 2009 |
d8 DE, Pdx1(GFP)+> 5, compared with ES, ECT, LPM, PAM, Mesendoderm, d5 DE | APOE | apolipoprotein E | AK019319 | visceral endoderm |  | vascular | ― | ― |
|  | C2cd4b | C2 calcium-dependent domain containing 4B | AK014341 | AIP, posterior gut | trunk |  | associated with β-cell function | Diabetologia.,2010 |
|  | Chi3l1 | chitinase 3-like 1 | BC005611 | AIP |  |  | ― | ― |
| Â | CpM | carboxypeptidase M | AK004327 | AIP, lateral gut | Â | Â | lung | Am. J. Respir. Cell Mol. Biol. 1993 |
|  | Creb3l1 | cAMP responsive element binding protein 3-like 1 | BC016447 | - | epithelium | mesenchyme | ― | ― |
|  | Fam188b | RIKEN cDNA C330043M08 gene | BB667136 | AIP |  |  | ― | ― |
|  | Fhl2 | four and a half LIM domains 2 | NM_010212 | AIP, anterior gut |  |  | ― | ― |
| Â | Foxp4 | forkhead box P4 | BQ286886 | AIP, lateral gut | epithelium | Â | E9.5~, pulmonary, gut | Mech Dev. 2002 |
| Â | Hipk2 | homeodomain interacting protein kinase 2 | NM_010433 | AIP | epithelium | Â | E12.5~, pancreas | Endocrinology, 2009 |
|  | Irf6 | interferon regulatory factor 6 | NM_016851 | anterior gut, hindgut |  |  | ― | ― |
|  | Lbh | Limb-bud-and-heart | NM_029999 | AIP |  |  | ― | ― |
|  | Palld | 2410003B16Rik, Ig domain Palladin | NM_001081390 | dorsal gut |  |  | ― | ― |
|  | Pbxip1 | pre-B-cell leukemia transcription factor interacting protein 1 | AV220340 | AIP | trunk |  | ― | ― |
|  | Pcbd1 | pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 (TCF1) | NM_025273 | AIP | epithelium |  |  | ― |
| Â | Pcdh1 | protocadherin 1 | AK008111 | - | tip | mesenchyme | E12.5~ blood vessels of the gut | Dev Dyn.,2008 |
| Â | Sox4 | SRY-box containing gene 4 | AI428101 | AIP, lateral gut | epithelium | Â | E12.4~, pancreas | Dev Dyn.,2003 |
| Â | Tcf7l2 | transcription factor 7-like 2, T-cell specific, HMG-box | BM218908 | AIP, lateral gut | epithelium | mesenchyme | diabetes risk gene | Nat. Genet.2006 |
|  | Zmiz1 | zinc finger, MIZ-type containing 1 | NM_183208 | AIP, lateral gut |  |  |  | ― |
d7 DE/d5 DE > 5 | Aebp2 | AE binding protein 2 | BB667191 | whole gut | epithelium |  | ― | ― |
|  | Barhl2 | BarH-like 2 (Drosophila) | NM_001005477 | lateral gut |  |  | ― | ― |
d8 DE Pdx1(GFP)+/Pdx1(GFP)- > 2 | Kiss1r | KISS1 receptor | NM_053244 | lateral gut | Â | Â | mouse islets | Diabetologia.,2006 |