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Table 2 Functional annotation clustering of 199 DAVID IDs that were upregulated in hiPS-BCs vs hES-BCs.

From: Global transcriptional profiles of beating clusters derived from human induced pluripotent stem cells and embryonic stem cells are highly similar

GO term

Category

No. of genes

p- value

Genes

ECM-receptor interactions

KEGG pathway

12

2.7E-9

CD47, CD36, COL4A1, CD44, COL6A3, COL3A1, COL1A2, RELN, COL1A1, LAMB1, COL5A2, COL5A1

Collagen

Cellular component

9

4.5E-9

COL4A1, LUM, COL6A3, COL3A1, COL1A2, COL12A1, COL1A1, COL5A2, COL5A1

Fibrillar collagen

Cellular component

6

1.4E-7

LUM, COL3A1, COL1A2, COL1A1, COL5A2, COL5A1

Tissue development

Biological process

20

3.3E-4

EDN3, CAV1, PPHLN1, COL3A1, ANXA1, KITLG, POSTN, SNAI2, COL5A2, COL5A1, CD44, HOXA5, CTGF, HOXB5, HLX, PRKAR1A, COL1A2, COL1A1, NR2F2, PITX1

Skin development

Biological process

5

3.6E-4

COL3A1, COL1A2, COL1A1, COL5A2, COL5A1

Focal adhesion

KEGG pathway

10

5.7E-4

CAV1, COL4A1, COL6A3, COL3A1, COL1A2, RELN, COL1A1, LAMB1, COL5A2, COL5A1

  1. GO-terms that were significantly overrepresented (enrichment score > 3, p < 0.001,) and genes included in each category are shown. The GO-terms shown in this table all belong to the same annotation cluster with the enrichment score of 4.56.