Table 2 Trophoblast differentiation associated genes
From: Phosphatidylinositol 3 kinase modulation of trophoblast cell differentiation
Gene name | Abbreviation | Synonyms | Functional Group | GenBank Accession No. | Fold Change D/S | Fold Change D/D+LY |
|---|---|---|---|---|---|---|
Keratin complex 1, acidic, gene 19 | Krt19 | EndoC, K19 | Cytoskeletal protein | NM_199498 | 149.07t | - |
Carcinoembryonic antigen gene family 4 | Cgm4 | Psg16, Psg38 | Secretory protein, unknown function | NM_012525 | 89.73 | -2.79 |
Carcinoembryonic antigen-related cell adhesion molecule 3 | Ceacam3 | Cgm1 | Cell adhesion molecule | NM_012702 | 88.71 | -1.75 |
Cytochrome P450, family 11, subfamily a, polypeptide 1 | Cyp11a1 | P450scc | Steroidogenic enzyme | NM_017286 | 47.11 | - |
Prolactin family 4, subfamily a, member 1 | Prl4a1 | PLP-A | Ligand/cytokine | NM_017036 | 33.05 | -3.91 |
Spleen protein 1 precursor | Rsp1 | Sslp1, LOC171573 | Unknown | NM_138537 | 30.29 | -4.43 |
Solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 | Slc28a2 | Cnt2 | Transporter, nucleotide | NM_031664 | 23.94 | -1.71 |
Interleukin 17F | Il17f | ML1 | Ligand/cytokine | NM_001015011 | 22.49 | -2.61 |
Fibronectin 1 | Fn1 | Fn | Extracellular matrix protein | NM_019143 | 19.68 | - |
H19 fetal liver mRNA | H19 | ASM1 | Unknown | NR_027324 | 13.10 | - |
Cytochrome P450, family 17, subfamily a, polypeptide 1 | Cyp17a1 | Cyp17, p450c17 | Steroidogenic enzyme | NM_012753 | 10.76 | -4.57 |
Hydroxysteroid (17-beta) dehydrogenase 2 | Hsd17b2 | Â | Steroidogenic enzyme | NM_024391 | 10.56 | -- |
Placenta-specific 1 | Plac1 | Epcs26 | Cell-cell comunication | NM_001024894 | 9.62 | -- |
CEA-related cell adhesion molecule 10 | Ceacam10 | C-CAM4 | Cell adhesion molecule | NM_173339 | 8.66 | -1.86 |
Differentaly expressed X chromosome EST 1 | Dif EST 1 | Â | Â | AI012949 | 8.61 | -- |
Prolactin family 3, subfamily b, member 1 | Prl3b1 | PL-II, Csh2 | Ligand/cytokine | NM_012535 | 8.38 | -7.73 |
CD47 antigen (Rh-related antigen, integrin-associated signal transducer) | Cd47 | IAP, Itgp | Receptor, thrombospondin | NM_019195 | 7.90 | - |
Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D | Sema6d | Â | Receptor | NM_001107768 | 8.38 | -1.56 |
Differentaly expressed X chromosom EST 2 | Dif EST 2 | LOC681066 | Â | AA964255 | 7.40 | - |
Serine (or cysteine) peptidase inhibitor, clade E, member 1 | Serpine1 | Pai1, Planh | blood coagulation, angiogenesis | NM_012620 | 6.41 | -3.95* |
Extracellular matrix protein 1 | Ecm1 | Â | Extracellular protein | NM_053882 | 6.11 | - |
Adrenomedullin | Adm | Â | Hypotensive peptide | NM_012715 | 5.81 | -14.40 |
Moesin | Msn | Â | Cell-cell comunication | NM_030863 | 5.66 | - |
DNA-damage inducible transcript 3 | Ddit3 | Chop10, Gadd153 | Cell stress/death | NM_001109986 | 5.65 | -1.86 |
Melanoma antigen, family D, 1 | Maged1 | Nrage, Dlxin1 | Apoptosis, cell cycle, transcription | NM_053409 | 5.61 | - |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | Cited2 | Mrg1, Msg2, p35srj | Transcription regulator | NM_053698 | 5.49 | - |
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | Hsd3b1 | Â | Steroidogenic enzyme | NM_001007719 | 5.15 | - |
Fos-like antigen 1 | Fosl1 | Fra1 | Transcription regulator | NM_012953 | 5.04 | - |
Legumain | Lgmn | Prsc1 | Putative cysteine protease | NM_022226 | 4.73 | - |
Insulin-like growth factor 2 | Igf2 | Igf-II | Ligand, growth factor | NM_031511 | 4.38 | -3.74 |
Tribbles homolog 3 (Drosophila) | Trib3 | Trb3, Ifld2, Nipk | Metabolism | NM_144755 | 4.37 | -2.09 |
High mobility group box transcription factor 1 | Hbp1 | HMGB1 | Transcription regulator | NM_013221 | 4.36 | - |
Cathepsin D | Ctsd | CD, CatD | Lysosomal aspartic endopeptidase | NM_134334 | 4.13 | -3.00 |
Matrix metallopeptidase 9 | Mmp9 | Gelatinase B | Extracellular matrix remodeling | NM_031055 | 4.00 | -3.11 |
Fas ligand (TNF superfamily, member 6) | Faslg | Faslg, Tnfsf6 | Ligand/membrane anchored | NM_012908 | 3.80 | -3.06 |
Reproductive homeobox on X chromosome, 9 | Rhox9 | Gpbox, Psx2 | Transcription regulator | NM_001024874 | 3.43 | - |
Granulin | Grn | Gep, Pcdgf, Pgrn | Ligand, growth factor | NM_017113 | 3.39 | - |
CD9 antigen | Cd9 | Tspan29 | Cell surface glycoprotein | NM_053018 | 3.14 | - |
RhoB gene | Rhob | Arhb | Ras family | NM_022542 | 3.07 | 2.08* |
Phosphatidylinositol 3-kinase, catalytic, beta polypeptide | Pik3cb | Â | Inositol lipid kinase | NM_053481 | 2.75 | - |
Kruppel-like factor 2 (lung) | Klf2 | Â | Transcription regulator | NM_001007684 | 2.73 | 4.70 |
Jun-B oncogene | Junb | Â | Transcription regulator | NM_021836 | 2.35 | - |
Tissue factor pathway inhibitor | Tfpi | EPI, LACI | Kunitz family serine protease inhibitor | NM_017200 | 2.20 | - |
Nuclear factor, erythroid derived 2, like 2 | Nfe2l2 | Nrf2 | Transcription regulator | NM_031789 | 2.09 | - |